24897-52-7Relevant academic research and scientific papers
Synthesis of C8-N9 annulated purines by iron-catalyzed C-H amination
Maes, Jens,Rauws, Tom R. M.,Maes, Bert U. W.
supporting information, p. 9137 - 9141 (2013/07/26)
Purine and simple: A short synthesis for substituted annulated purine derivatives based on an Fe-catalyzed direct amination reaction using oxygen as oxidant was developed (see scheme). Interestingly, iron proved to be superior to copper catalysis. Copyright
Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide
Sajiki, Hironao,Esaki, Hiroyoshi,Aoki, Fumiyo,Maegawa, Tomohiro,Hirota, Kosaku
, p. 1385 - 1388 (2007/10/03)
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D 2O media. Georg Thieme Verlag Stuttgart.
Synthesis of base-selectively deuterium-labelled nucleosides by the Pd/C-catalyzed H-D exchange reaction in deuterium oxide
Esaki, Hiroyoshi,Aoki, Fumiyo,Maegawa, Tomohiro,Hirota, Kosaku,Sajiki, Hironao
, p. 361 - 369 (2007/10/03)
The D2 gas-free and base-selective H-D exchange reaction of nucleosides was developed. It discloses a convenient route to the post-synthetic incorporation of deuteriums into the base moiety of nucleic acids with high deuterium efficiency.
METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING
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Page/Page column 16-17, (2008/06/13)
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.
HOMOGENEOUS HYDROGENOLYSIS OF THE C-I BOND; PREPARATION OF 2H>URACIL
Rocek, Josef,Svata, Vladimir,Leseticky, Ladislav
, p. 1244 - 1248 (2007/10/02)
Reductive dehalogenation of 5-iodouracil by deuterium, catalysed by coordination compounds of transition metals, has been studied.Conditions were found under which the deuteration product contained 80percent of 2H>uracil and less than 2percent of 2H2>uracil.
Nucleic acid bases studed by matrix isolation vibrational spectroscopy: uracil and deuterated uracils
Barnes, A. J.,Stuckey, M. A.,Gall, L. Le
, p. 419 - 432 (2007/10/02)
A vibrational assignment of the isolated uracil molecule is presented, based on i.r. and Raman spectra of uracil trapped in argon and nitrogen matrices and i.r. spectra of seven deuterated derivatives of uracil isolated in argon matrices.The observed spectra agree well with previous quantumm mechanical calculations.The relationships observed between the monomer bands, bands due to associated uracil in argon matrices and the spectrum of the pure solid lead to a revised vibrational assignment for uracil in the solid phase.As well as large shifts in the NH stretching and out-of-plane bending modes between the monomer and the hydrogen-bonded solid, many other bands show appreciable shifts as a consequence of the extensive mixing of the NH in-plane bending modes with the CH in-plane bending and ring stretching modes.The spectrum of the associated uracil species in matrices suggests that it is a cyclic dimer linked by C2=O...H-N1 hydrogen bonds.
