24914-10-1

Basic information

• Product Name: 2-(4-chlorophenyl)-N-cyclohexyl-2-oxoacetamide
• Synonyms: 2-(4-chlorophenyl)-N-cyclohexyl-2-oxoacetamide
• CAS NO: 24914-10-1
• Molecular Weight: 265.74
• Mol File: 24914-10-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-N-cyclohexyl-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-N-cyclohexyl-2-oxoacetamide(24914-10-1)
• EPA Substance Registry System: 2-(4-chlorophenyl)-N-cyclohexyl-2-oxoacetamide(24914-10-1)

Safety Data

• Hazardous Substances Data: 24914-10-1(Hazardous Substances Data)

Upstream product

• 484644-41-9 2-(4-chlorophenyl)-N-cyclohexyl-8-methyl-imidazo[1,2-a]pyridin-3-amine 
• 931-53-3 Cyclohexyl isocyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 108-91-8 cyclohexylamine 

Relevant articles and documents

Optimized conditions for Passerini-Smiles reactions and applications to benzoxazinone syntheses

Initial conditions disclosed for the Passerini-Smiles reaction are associated with a lack of efficiency that has prevented chemists from using it since its discovery. We wish to report herein our thorough study in the development of new experimental conditions for this coupling between electron-poor phenols, isocyanides, and carbonyl derivatives. These new conditions have been applied to several synthetic strategies towards benzoxazinones.

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

Ligand-Free Pd-Catalyzed Double Carbonylation of Aryl Iodides with Amines to α-Ketoamides under Atmospheric Pressure of Carbon Monoxide and at Room Temperature

A general Pd-catalyzed double carbonylation of aryl iodides with secondary or primary amines to produce α-ketoamides at atmospheric CO pressure has been developed. This transformation proceeds successfully even at room temperature and in the absence of any ligand and additive. A wide range of aryl iodides and amines can be coupled to the desired α-ketoamides in high yields with excellent chemoselectivities. Importantly, the current methodology has been demonstrated to be applied in the synthesis of bioactive molecules and chiral α-ketoamides.