24919-52-6Relevant academic research and scientific papers
Simple synthesis, structure and ab initio study of 1,4-benzodiazepine-2,5- diones
Jadidi, Khosrow,Aryan, Reza,Mehrdad, Morteza,Lügger, Thomas,Ekkehardt Hahn,Ng, Seik Weng
, p. 37 - 42 (2004)
A simple procedure for the synthesis of pyrido[2,1-c][1,4] benzodiazepine-6,12-dione (1) and 1,4-benzodiazepine-2,5-diones (2a-2d), using microwave irradiation and/or conventional heating is reported. The configuration of 1 was determined by single-crysta
Solid phase synthesis of 1,4-benzodiazepine-2,5-diones
Mayer, John P.,Zhang, Jingwen,Bjergarde, Kirsten,Lenz, Doug M.,Gaudino, John J.
, p. 8081 - 8084 (2007/10/03)
1,4-benzodiazepine-2,5-diones were synthesized by a simple procedure utilizing polymer supported amino acids and o-nitrobenzoic acids or protected anthranilic acids. Cyclization of the common aminoamide intermediate with concomitant release from the support furnished the desired 1,4-benzodiazepine-2,5-diones. The products were recovered in high yields and exhibited excellent purities.
A Versatile Synthesis of 3H-1(H),4(H)-Benzodiazepin-2,5-diones
Mohiuddin, G.,Reddy, P. S. N.,Ahmed, Khalil,Ratnam, C. V.
, p. 905 - 907 (2007/10/02)
Reaction of isatoic anhydrides (1) and α-amino acids (2) in glacial acetic acid under reflux gave 3H-1(H),4(H)-benzodiazepin-2,5-diones (3) in good yields.These compounds have been characterised by UV, IR, mass, PMR and 13C-NMR spectra.
