2492-75-3

Basic information

• Product Name: 2-oxohexanoic acid
• Synonyms: 2-Ketohexanoic acid;2-oxohexanoic acid;2-Ketocaproic acid;2-Oxocaproic acid;Hexanoic acid, 2-oxo-
• CAS NO: 2492-75-3
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.14
• Mol File: 2492-75-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 198.7°Cat760mmHg
• Flash Point: 88.3°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.15mmHg at 25°C
• Refractive Index: 1.439
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-oxohexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxohexanoic acid(2492-75-3)
• EPA Substance Registry System: 2-oxohexanoic acid(2492-75-3)

Safety Data

• Hazardous Substances Data: 2492-75-3(Hazardous Substances Data)

Usage

Uses

2-Oxohexanoic Acid (cas# 2492-75-3) has been useful in a biological study that investigated the impact of glutathione on wines oxidative stability.

Definition

ChEBI: A straight-chain fatty acid consisting of hexanoic acid having an oxo group at position 2.

InChI:InChI=1/C6H10O3/c1-2-3-4-5(7)6(8)9/h2-4H2,1H3,(H,8,9)

Upstream product

• 328-50-7 α-ketoglutaric acid 
• 327-56-0 D-norleucine 

Downstream Products

• 5753-96-8 ethyl 2-oxohexanoate 
• 110-62-3 pentanal 
• 327-56-0 D-norleucine 
• 127-17-3 2-oxo-propionic acid 
• 327-57-1 L-Norleucine 
• 98-86-2 acetophenone 
• 130317-29-2 2-Oxo-hexanoic acid benzyl ester 
• 57989-76-1 4-amino-6-butyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one 
• 80465-46-9 (S)-2-((Z)-2-Acetylamino-hex-2-enoylamino)-3-phenyl-propionic acid ethyl ester 
• 80465-41-4 (S)-2-(2-Oxo-hexanoylamino)-3-phenyl-propionic acid ethyl ester 

Relevant articles and documents

Characterization of d-amino acid aminotransferase from Lactobacillus salivarius

We searched a UniProt database of lactic acid bacteria in an effort to identify d-amino acid metabolizing enzymes other than alanine racemase. We found a d-amino acid aminotransferase (d-AAT) homologous gene (UniProt ID: Q1WRM6) in the genome of Lactobacillus salivarius. The gene was then expressed in Escherichia coli, and its product exhibited transaminase activity between d-alanine and α-ketoglutarate. This is the first characterization of a d-AAT from a lactic acid bacterium. L. salivarius d-AAT is a homodimer that uses pyridoxal-5′-phosphate (PLP) as a cofactor; it contains 0.91 molecules of PLP per subunit. Maximum activity was seen at a temperature of 60 °C and a pH of 6.0. However, the enzyme lost no activity when incubated for 30 min at 30 °C and pH 5.5 to 9.5, and retained half its activity when incubated at pH 4.5 or 11.0 under the same conditions. Double reciprocal plots of the initial velocity and d-alanine concentrations in the presence of several fixed concentrations of α-ketoglutarate gave a series of parallel lines, which is consistent with a Ping-Pong mechanism. The Km values for d-alanine and α-ketoglutarate were 1.05 and 3.78 mM, respectively. With this enzyme, d-allo-isoleucine exhibited greater relative activity than d-alanine as the amino donor, while α-ketobutylate, glyoxylate and indole-3-pyruvate were all more preferable amino acceptors than α-ketoglutarate. The substrate specificity of L. salivarius d-AAT thus differs greatly from those of the other d-AATs so far reported.

Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme

-