2492-83-3

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL
• Synonyms: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL;2-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE;2-(4-chlorophenyl)ethanaMine hydrochloride
• CAS NO: 2492-83-3
• Molecular Formula: C₈H₁₀ClN*ClH
• Molecular Weight: 192.09
• Mol File: 2492-83-3.mol

Chemical Properties

• Boiling Point: 233.4°Cat760mmHg
• Flash Point: 107.5°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 0.00504mmHg at 25°C
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(2492-83-3)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(2492-83-3)

Safety Data

• Hazardous Substances Data: 2492-83-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL is used as a research chemical for studying the effects of serotonin and dopamine release in the brain. Its application is crucial in understanding the mechanisms of mood regulation and the pathophysiology of neurodegenerative diseases.
Used in Controlled Substance Regulation:
As a controlled substance, 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL is used in the regulatory framework to prevent its abuse and misuse. This application is essential for public health and safety, ensuring that the compound is only utilized in appropriate and supervised settings.
Used in Drug Development:
In the pharmaceutical industry, 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL is used as a lead compound in the development of new medications for mood disorders and neurodegenerative diseases. Its unique mechanism of action as a serotonin and dopamine releasing agent provides a basis for designing potential therapeutic agents.

InChI:InChI=1/C8H10ClN.ClH/c9-8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 328281-40-9 2-4-chlorophenylethylcarbamic acid methyl ester 

Downstream Products

• 40077-18-7 2-{[2-(4-Chloro-phenyl)-ethylamino]-methyl}-3,4-dihydro-2H-naphthalen-1-one 
• 18971-04-5 (E)-N-[2-(4-Chloro-phenyl)-ethyl]-3-(2,4-dichloro-phenyl)-acrylamide 
• 80554-83-2 N-[2-(4-Chloro-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide 
• 140677-22-1 N-[2-(4-Chloro-phenyl)-ethyl]-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide 
• 439116-80-0 2-(2-(tert-butoxycarbonylamino)ethyl)-5-chlorobenzyl azide 
• 439116-79-7 tert-butyl 2-[4-chloro-2-(hydroxymethyl)phenyl]-ethylcarbamate 
• 439116-12-8 tert-butyl 2-[2-(aminomethyl)-4-chlorophenyl]ethylcarbamate 
• 22245-95-0 7-chloro-1,2,3,4-tetrahydroisoquinolin-1-one 
• 55121-08-9 1-chloro-3-(2-isocyanatoethyl)benzene 
• 140677-23-2 N-[2-(4-Chloro-phenyl)-ethyl]-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide 

Relevant articles and documents

Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane

Herein we report the synthesis of primary and secondary amines by nitrile hydrogenation, employing a borrowing hydrogenation strategy. A class of phosphine-free manganese(I) complexes bearing sulfur side arms catalyzed the reaction under mild reaction conditions, where ammonia-borane is used as the source of hydrogen. The synthetic protocol is chemodivergent, as the final product is either primary or secondary amine, which can be controlled by changing the catalyst structure and the polarity of the reaction medium. The significant advantage of this method is that the protocol operates without externally added base or other additives as well as obviates the use of high-pressure dihydrogen gas required for other nitrile hydrogenation reactions. Utilizing this method, a wide variety of primary and symmetric and asymmetric secondary amines were synthesized in high yields. A mechanistic study involving kinetic experiments and high-level DFT computations revealed that both outer-sphere dehydrogenation and inner-sphere hydrogenation were predominantly operative in the catalytic cycle.

Visible Light-Mediated Decarboxylation Rearrangement Cascade of Aryl- N-(acyloxy)phthalimides

A Smiles-type radical rearrangement induced by visible-light-mediated decarboxylation of w-aryl-N-(acyloxy)phthalimides was developed, giving rise to pharmacologically important substance classes: phenylethylamine derivatives, dihydroisoquinolinones, and

Hydrogenation of Nitriles and Ketones Catalyzed by an Air-Stable Bisphosphine Mn(I) Complex

Efficient hydrogenations of nitriles and ketones with molecular hydrogen catalyzed by a well-defined bench-stable bisphosphine Mn(I) complex are described. These reactions are environmentally benign and atomically economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. A range of aromatic and aliphatic nitriles and ketones were efficiently converted into primary amines and alcohols, respectively, in good to excellent yields. The hydrogenation of nitriles proceeds at 100 °C with catalyst loading of 2 mol % and 20 mol % base (t-BuOK), while the hydrogenation of ketones takes place already at 50 °C, with a catalyst loading of 1 mol % and 5 mol % of base. In both cases, a hydrogen pressure of 50 bar was applied.

Novel Borane-Selenium Complex: Highly Selective Reduction of Tertiary Amides and Nitriles to the Corresponding Amines with Sodium Borohydride-Dialkylselenium Dibromide

The reaction of sodium borohydride with bis(2-bromoethyl)selenium dibromide and/or diethylselenium dibromide in tetrahydrofuran (THF) gave borane.Treatment of tertiary amides with mixtures of sodium borohydride and either of the dibromides in THF gave the corresponding amines.Similar reactions with secondary and primary amides did not proceed.Furthermore, under similar reduction conditions, the reaction of nitriles with the above reagents also gave the corresponding primary amines.