24924-53-6Relevant academic research and scientific papers
One-pot triflic anhydride-mediated synthesis of 1,2-disubstituted 2-imidazolines from N-(2-haloethyl)amides and amines
Ellsworth, Alyssa A.,Magyar, Christina L.,Hubbell, Grace E.,Theisen, Chelsea C.,Holmes, Daniel,Mosey, R. Adam
, p. 6380 - 6389 (2016/09/23)
A one-pot synthesis of 1,2-disubstituted 2-imidazolines from N-(2-haloethyl)amides has been developed. The reaction affords high yields of diverse 1,2-disubstituted 2-imidazolines from triflic anhydride-mediated dehydration of amides followed by installat
Copper-catalyzed N -arylation of 2-imidazolines with aryl iodides
Davis, Owen A.,Hughes, Matthew,Bull, James A.
, p. 3470 - 3475 (2013/06/26)
The first copper-catalyzed N-arylation of 2-imidazolines is described. The reaction affords compounds with desirable lead-like characteristics in high yield with practical simplicity under inexpensive, ligand-free conditions. The cross coupling was successful with electron-rich and electron-poor aromatic iodides. Substrates bearing halides, esters, nitriles, and free hydroxyls are well tolerated, providing reactive handles for further functionalization, as are pyridines. In addition, the regioselective N-arylation of a 4-substituted imidazoline is reported.
New cycloplatinated complexes with 2-arylimidazolines: Synthesis, crystal structures and photophysical properties
Gong, Jun-Fang,Fan, Xin-Heng,Xu, Chen,Li, Jin-Lei,Wu, Yang-Jie,Song, Mao-Ping
, p. 2006 - 2013 (2007/10/03)
The synthesis, crystal structures and photophysical properties of a series of cycloplatinated complexes are presented. The complexes have the general formula (C∧N)Pt(O∧O), where O∧O is acetylacetonate and C∧N re
Nucleophilic Addition to Substituted 1H-4,5-Dihydroimidazolium Salts
Salerno, Alejandra,Ceriani, Vanina,Perillo, Isabel A.
, p. 709 - 716 (2007/10/03)
1H-4,5-Dihydroimidazolium salts 1 react readily with nucleophilic reagents originating cyclic products which may be stable or become transformed into acyclic compounds maintaining the structural ethylenediamine unit. With methylmagnesium iodide compound le affords the expected imidazolidine, but in the case of substituted 1-aryl-3-methyl-2-phenyl salts 1b-d the N-aryl-N'-methylethylenediamines 3b-d and acetophenone (4) were isolated, the process representing the transfer of the C-2 unit to a nucleophilic carbon. With alkaline cyanides salts 1 react efficiently affording α,α-diaminonitriles 5. In these compounds the cyano group may be readily substituted by nucleophiles (hydroxyl anion, species with nucleophilic carbon and reagents that act by hydride ion transfer), in a way similar to the salts but with better yields.
