5450-86-2

Basic information

• Product Name: 4-aminobenzenesulfonohydrazide
• Synonyms: 4-aminobenzenesulfonohydrazide
• CAS NO: 5450-86-2
• Molecular Formula: C₆H₉N₃O₂S
• Molecular Weight: 187.2196
• Mol File: 5450-86-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 414.2 °C at 760 mmHg
• Flash Point: 204.3 °C
• Appearance: /
• Density: 1.445 g/cm³
• Vapor Pressure: 4.52E-07mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 4-aminobenzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aminobenzenesulfonohydrazide(5450-86-2)
• EPA Substance Registry System: 4-aminobenzenesulfonohydrazide(5450-86-2)

Safety Data

• Hazardous Substances Data: 5450-86-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H9N3O2S/c7-5-1-3-6(4-2-5)12(10,11)9-8/h1-4,9H,7-8H2

Upstream product

• 80414-97-7 N-acetyl-N'-(N-acetyl-sulfanilyl)-hydrazine 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 80414-98-8 N'N'-diacetyl p-acetamidobenzenesulfonohydrazide 
• 3989-50-2 4-acetamidobenzenesulfonylhydrazine 
• 7647-01-0 hydrogenchloride 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 100115-09-1 1-[2]thienyl-ethanone-sulfanilylhydrazone 
• 5462-37-3 sulfanilic acid-(1,3-dimethyl-but-2-enylidenehydrazide) 
• 5448-65-7 sulfanilic acid cyclohexylidenehydrazide 
• 5448-67-9 3-sulfanilylhydrazono-butyric acid ethyl ester 
• 6335-09-7 sulfanilic acid-(4-methoxy-benzylidenehydrazide) 
• 14294-41-8 4-methyl-1-sulfanilyl thiosemicarbazide 
• 5462-40-8 sulfanilic acid-(1-phenyl-ethylidenehydrazide) 
• 1137-77-5 4-(4-methoxyphenyl)aniline 
• 92-67-1 4-phenylalanine 
• 169590-42-5 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide 
• 1261066-30-1 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[(4-aminophenyl)sulfonamido-1-yl]quinazolin-4(3H)one 
• 1200355-93-6 1-(4'aminophenylsulfonylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl ester 
• 5448-61-3 acetone sulfanilohydrazone 

Relevant articles and documents

SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacoph

Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom

The current treatment used against envenomation by Lachesis muta venom still presents several side effects. This paper describes the synthesis, pharmacological and theoretical evaluations of new 1-arylsulfonylamino-5-methyl- 1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters (8a-f) tested against the hemolytic profile of the L muta snake venom. Their structures were elucidated by one- and two-dimensional NMR techniques (1H, APT, HETCOR 1JCH and 11JCH,. n = 2, 3) and high-resolution electrospray ionization mass spectrometry. The series of triazole derivatives significantly neutralized the hemolysis induced by L. muta crude venom presenting a dose-dependent inhibitory profile (IC50- 30-83 μM) with 1-(4'chlorophenylsulfonylamino)-5-methyl-1 H-[1,2,3 ]-triazole-4-carboxylic acid ethyl ester (8e) being the most potent compound. The theoretical evaluation revealed the correlation of the antiophidian profile with the coefficient distribution and density map of the Highest Occupied Molecular Orbitals (HOMO) of these molecules. The elucidation of this new series may help on designing new and more efficient antiophidian molecules.