249509-29-3

Basic information

• Product Name: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine
• Synonyms: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine
• CAS NO: 249509-29-3
• Molecular Weight: 284.315
• Mol File: 249509-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine(249509-29-3)
• EPA Substance Registry System: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine(249509-29-3)

Safety Data

• Hazardous Substances Data: 249509-29-3(Hazardous Substances Data)

Upstream product

• 139416-71-0 1-(o-tolyl)prop-2-yn-1-ol 
• 52522-99-3 2,4-dimethoxy-5-iodopyrimidine 

Downstream Products

• 249509-33-9 2,4-dimethoxy-5-(o-toluoylethynyl)pyrimidine 

Relevant articles and documents

5-(Acylethynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5- (Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities

5-(acylethynyl)uracils 4 were synthesized from 5-iodo-2,4- dimethoxypyrimidine 1 through a palladium-catalyzed reaction with acetylenic carbinols 5, subsequent oxidation with manganese dioxide in dichloromethane, demethylation with 6 N hydrochloric acid, followed by treatment with sodium hydroxide in 95% ethanol. The corresponding 5-acylethynyl-2'-deoxyuridines 9 and 5-acylethynyl-1-(2hydroxyethoxy-methyl)uracils 13 were synthesized following a similar procedure. The 5-acylethynyluracils 4 were cytotoxic against murine L1210 and human T-lymphocyte (Molt 4/C8, CEM) cells. The 2'- deoxyuridine derivatives 9 were less cytotoxic; however the acyclonucleosides 13 were as active as the free bases 4. The compounds did not have antiviral activities at subtoxic concentrations.