249537-73-3

Usage

Uses

1. Used in Pharmaceutical Applications:
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH is used as a NFAT inhibitor for studying the signaling pathways involved in controlling inhibitory molecules and the subsequent onset of T-cell impairment. It selectively inhibits calcineurin-mediated dephosphorylation of NFAT without disrupting other calcineurin-dependent pathways, making it a valuable tool in understanding and potentially treating T-cell related conditions.
2. Used in Research Applications:
In research, H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH can be used as a specific peptide sequence to investigate the roles of individual amino acids and their interactions within larger protein structures. This can help in understanding protein folding, stability, and function, as well as in the development of new drugs and therapies targeting specific proteins.
3. Used in Drug Delivery Systems:
Similar to gallotannin, if H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH has potential therapeutic properties, it could be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. This may involve the use of organic or metallic nanoparticles as carriers for targeted delivery to specific cells or tissues.
4. Used in Anticancer Applications (if applicable):
If H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH demonstrates anticancer properties, it could be used as an anticancer agent, potentially against various types of cancer. It may modulate oncological signaling pathways and exhibit synergistic effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.