24954-15-2Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes
Barrios-Rivera, Jonathan,Xu, Yingjian,Clarkson, Guy J.,Wills, Martin
supporting information, (2021/12/02)
The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.
Chemo- and Regioselective Asymmetric Friedel-Crafts Reaction of Furans and Thiophenes with α,β-Unsaturated Aldehydes through Dual Activation
Zhang, Xiao-Ru,Zhou, Su-Lan,Yuan, Yi,Du, Wei,Chen, Ying-Chun
supporting information, p. 1771 - 1774 (2017/09/30)
A highly chemo- and regioselective Friedel-Crafts alkylation reaction of furans and thiophenes has been developed, which relies on the activation from the remote conjugated Mukaiyama silyl enol ether motif. Excellent enantioslectivity is generally obtained in reactions with α,β-unsaturated aldehydes under the well-established iminium ion catalysis of a chiral secondary amine.
Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis
Hashmi, A. Stephen K.,W?lfle, Michael
experimental part, p. 9021 - 9029 (2009/12/08)
A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans.
2-ACYLAMINOTHIAZOLE DERIVATIVES
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Page/Page column 26, (2008/06/13)
The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A2A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
Regioselective synthesis of functionalized furans by cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane
Bellur, Esen,Goerls, Helmar,Langer, Peter
, p. 2074 - 2090 (2007/10/03)
Cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane allowed an efficient, regio- and diastereo-selective synthesis of a variety of 2-alkylidene-4-methoxy-tetrahydrofurans. The TFA-mediated elimination of methanol resulted in the formation of functionalized furans. Simi larly, 2,3,3a,4,5,6-hexahydro-2,3-benzofurans were prepared and transformed into 4,5,6,7-tetrahydro-2,3-benzofurans by treatment with TFA Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
Unusual Rearrangement of Fischer Carbene Complexes to Ketones
Nandi, Malay,Sathe, Kashinath M.,Sarkar, Amitabha
, p. 793 - 794 (2007/10/02)
A thermal rearrangement of aryl arylmethoxy carbene complexes of chromium and tungsten to aryl arylmethyl ketones is described for the first time.
SILVER TRIFLATE-PROMOTED COUPLING REACTIONS OF BENZYLIC AND ALLYLIC SULFIDES WITH O-SILYLATED ENOLATES OF KETONES AND ESTERS, A SYNTHESIS OF (+/-)-AR-TURMERONE
Takeda, Kazuyoshi,Torii, Katsumi,Ogura, Haruo
, p. 265 - 266 (2007/10/02)
Reactions of benzylic and allylic sulfides 1 having 5-mercapto-1-phenyl-1H-tetrazolyl group with O-silylated ketone and ester enolates 2 in the presence of silver triflate gave coupling products 3 in good yield. (+/-)-ar-turmerone was synthesized by this
