249608-63-7

Upstream product

• 17639-64-4 N-p-toluenesulfonylpyrrole 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 1071478-76-6 C₁₈H₁₆N₂O₄S 
• 249608-65-9 C₁₈H₁₆N₂O₃S 
• 336812-10-3 (2-nitrophenyl)(1-methyl-1H-pyrrol-3-yl)methanone 
• 336812-12-5 (2-nitrophenyl)(1-methyl-1H-pyrrol-3-yl)methanol 
• 336812-04-5 (2-nitrophenyl)(1H-pyrrol-3-yl)methanone 

Relevant academic research and scientific papers

Synthesis of new pyrrolobenzazepines via Pictet-Spengler cyclization

A new six-step divergent strategy was developed allowing access to pyrrolobenzazepine structures from pyrrole. This strategy was based on a regioselective Friedel-Crafts acylation followed by a Pictet-Spengler cyclization. Georg Thieme Verlag Stuttgart.

Reduction of 2- and 3-acylpyrroles. A new synthesis of the pyrrolo[1,2-b]cinnolin-10-one ring system from 1-(4-methylphenyl)sulfonyl-1H-pyrrole

Reduction of (2-nitrophenyl)(1H-pyrrol-2-yl)methanone 4 with zinc and ammonium chloride gave 5,10-dihydro-pyrrolo[1,2-b]cinnolin-10-one 5 and (2-hydroxylaminophenyl)(1H-pyrrol-2-yl)methanone 6 whereas reduction of 4 with zinc and sodium hydroxide gave only 5. Reaction of (2-nitrophenyl)(1H-pyrrol-3-yl)methanone 10 with zinc and ammonium chloride or zinc and sodium hydroxide afforded (2-nitrosophenyl)(1H-pyrrol-3-yl)methanone 11 and 2-aminophenyl)(1H-pyrrol-3-yl)methanone 12 or 12 as a single product, respectively. Sodium borohydride reduction of (2-nitrophenyl)(1-methyl-1H-pyrrol-2-yl)methanone 13 or (2-nitrophenyl)(1-methyl-1H-3-pyrrolyl)methanone 19 gave a mixture of the corresponding alcohols 15 or 21 and nitroso-ketones 18 or 22. Reduction of alcohols 15 or 21 with zinc and sodium hydroxide afforded nitroso-ketones 18 or 22, respectively. (C) 2000 Elsevier Science Ltd.