249608-66-0Relevant academic research and scientific papers
Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells
Rotas, Georgios,Natchkebia, Ketevan,Natsvlishvili, Nino,Kekelidze, Merab,Kimbaris, Athanasios,Varvounis, George,Mikeladze, David
, p. 3220 - 3223 (2005)
We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 wer
