249608-70-6

Upstream product

• 249608-64-8 (2-amino-phenyl)-[1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]-methanone 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 118-92-3 anthranilic acid 
• 249608-62-6 {1-[(4-methylphenyl)sulfonyl]-1H-pyrrol-2-yl}(2-nitrophenyl)methanone 

Downstream Products

• 249608-72-8 (2-isothiocyanatophenyl)(1H-pyrrol-2-yl)methanone 
• 1334215-07-4 N-[3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6-(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide 
• 1334215-09-6 N-methyl-2-(1H-pyrrol-2-ylmethyl)aniline 
• 1334215-11-0 6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine 
• 1334215-12-1 3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline 
• 861431-38-1 2-(2-isothiocyanato-benzyl)-1H-pyrrole 
• 249608-66-0 2-(1H-pyrrol-2-ylmethyl)-phenylamine 

Relevant academic research and scientific papers

Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents

Two new hypervalent iodine reagents containing furan and thiophene moieties in addition to a carbonyl group in the vicinity of the iodine atom were synthesised and characterised. The X-ray analysis of both compounds revealed a strong intramolecular contact between the carbonyl oxygen and the hypervalent iodine atom with tosylate as a counter ion. The two reagents showed a broad range of synthetic applications and proved to be versatile oxidizing agents.

Synthesis of a novel pyrrolo[1,2-c][1.3]benzodiazepine analogue of VPA-985

The seven-step synthesis of a novel structural isomer of VPA-985, N-[3-chloro-4-(5H-pyrrolo[1,2-c][1.3]benzodiazepin-6(11H)-ylcarbonyl)phenyl] -5-fluoro-2-methylbenzamide, is described. (2-Aminophenyl)(1H-pyrrol-2-yl) methanone was converted with thiophosgene into (2-isothiocyanatophenyl)(1H- pyrrol-2-yl)methanone which was cyclised in the presence of base to 5-thioxo-5,6-dihydro-11H-pyrrolo[1,2-c][1.3]benzodiazepin-11-one. The latter underwent desulfurisation with Raney nickel followed by reduction with lithium aluminium hydride in the presence of aluminium trichloride and the resulting 6,11-dihydro-5H-pyrrolo[1,2-c][1.3]-benzodiazepine acylated with 2-chloro-4-nitrobenzoyl chloride to afford 6-(2-chloro-4-nitrobenzoyl)-6,11- dihydro-5H-pyrrolo[1,2-c][1.3]benzodiazepine. The nitro group in the latter compound was reduced with zinc and ammonium chloride to give the corresponding aniline derivative which was then acylated with 2-methyl-5-fluorobenzoyl chloride to provide the final product.

Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells

We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 wer