249749-40-4

Upstream product

• 158395-13-2 (R)-3-Benzylsulfanyl-2-{(R)-3-benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-methyl-2-(3-phenyl-propionylamino)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionic acid methyl ester 
• 158395-14-3 (R)-3-Benzylsulfanyl-2-{(R)-3-benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-methyl-2-(3-phenyl-propionylamino)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionic acid 
• 143564-96-9 (R)-2-[(R)-2-((R)-2-Benzyloxycarbonylamino-3-benzylsulfanyl-2-methyl-propionylamino)-3-benzylsulfanyl-2-methyl-propionylamino]-3-benzylsulfanyl-2-methyl-propionic acid methyl ester 
• 158395-12-1 (R)-2-[(R)-2-((R)-2-Amino-3-benzylsulfanyl-2-methyl-propionylamino)-3-benzylsulfanyl-2-methyl-propionylamino]-3-benzylsulfanyl-2-methyl-propionic acid methyl ester 
• 249749-37-9 Boc-(R)-MeCys(Bn)-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 249749-35-7 Boc-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 249749-34-6 Boc-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 149639-95-2 Boc-L-Thr(Bn)-NHCH₃ 
• 96153-33-2 H-Thr(Bn)-NHCH₃ 
• 158395-16-5 C₆H₅CH₂CH₂CO-(R)-MeCys(Bn)-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 

Downstream Products

• 158395-17-6 (4R,4'S,4''S)-4,4',4''-Trimethyl-2''-phenethyl-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazole-4-carboxylic acid ((1S,2R)-2-hydroxy-1-methylcarbamoyl-propyl)-amide 

Relevant academic research and scientific papers

Total synthesis of thiangazole

A method for total synthesis of thiangazole (1), a tris-thiazoline- oxazole metabolite, is described. The key intermediate 9, a linear tetrapeptide amide composed of three S-benzyl-2-methylcysteine residues and a O-benzyl-threonine amide, was synthesized in 4 steps using 2-chloro-1,3- dimethyl-imidazolidium hexafluorophosphate(CIP)mediated activation. The successive thiazoline/oxazole rings were constructed by TiCl4mediated cycledehydration followed by acid-catalyzed Robinson-Gabriel reaction without difficulty.