149639-95-2Relevant articles and documents
Thio acid/azide amidation: An improved route to N-acyl sulfonamides
Barlett, Kristin N.,Kolakowski, Robert V.,Katukojvala, Sreenivas,Williams, Lawrence J.
, p. 823 - 826 (2007/10/03)
A one-pot procedure for the conversion of carboxylic acids to N-acyl sulfonamides, via thio acid/azide amidation, is presented. The method is compatible with acid- and base-sensitive amino acid protection. N-Acyl sulfonamide synthesis on solid support, pe
INHIBITORS OF ANTHRAX LETHAL FACTOR
-
Page/Page column 131, (2008/06/13)
Methods, compounds and compositions for preventing and treating anthrax infections by inhibiting Anthrax Lethal Factor (LF) activity.
Total synthesis of thiangazole
Akaji, Kenichi,Kiso, Yoshiaki
, p. 10685 - 10694 (2007/10/03)
A method for total synthesis of thiangazole (1), a tris-thiazoline- oxazole metabolite, is described. The key intermediate 9, a linear tetrapeptide amide composed of three S-benzyl-2-methylcysteine residues and a O-benzyl-threonine amide, was synthesized in 4 steps using 2-chloro-1,3- dimethyl-imidazolidium hexafluorophosphate(CIP)mediated activation. The successive thiazoline/oxazole rings were constructed by TiCl4mediated cycledehydration followed by acid-catalyzed Robinson-Gabriel reaction without difficulty.