149639-95-2

Upstream product

• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 593-51-1 methylamine hydrochloride 
• 84890-92-6 C₂₁H₃₁NO₇ 
• 817204-08-3 [(1S,2R)-2-Benzyloxy-1-(2-trimethylsilanyl-ethanesulfonylaminocarbonyl)-propyl]-carbamic acid tert-butyl ester 
• 881913-49-1 {(1S,2R)-2-Benzyloxy-1-[methyl-(2-trimethylsilanyl-ethanesulfonyl)-aminocarbonyl]-propyl}-carbamic acid tert-butyl ester 
• 137719-70-1 Boc-L-Thr(Bn)-OMe 
• 74-89-5 methylamine 

Downstream Products

• 96153-33-2 H-Thr(Bn)-NHCH₃ 
• 73535-42-9 Ac-L-Thr(OBn)-NHMe 
• 917774-02-8 β-D-Bz₄-Glc-Ac-L-Thr-NHMe 
• 863480-63-1 4-((1S,2R)-2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-butyric acid 
• 851983-96-5 4-((1S,2R)-2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-butyric acid tert-butyl ester 
• 851983-98-7 4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester 
• 249749-40-4 (2S,3R)-3-Hydroxy-2-((R)-3-mercapto-2-{(R)-3-mercapto-2-[(R)-3-mercapto-2-methyl-2-(3-phenyl-propionylamino)-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-N-methyl-butyramide 
• 158395-16-5 C₆H₅CH₂CH₂CO-(R)-MeCys(Bn)-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 249749-34-6 Boc-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 249749-35-7 Boc-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 
• 249749-37-9 Boc-(R)-MeCys(Bn)-(R)-MeCys(Bn)-(R)-MeCys(Bn)-Thr(Bn)-NHCH₃ 

Relevant academic research and scientific papers

Effect of β-O-glucosylation on L-Ser and L-Thr diamides: A bias toward α-helical conformations

β-D-O-glucosylation produces a remarkable effect on the peptide backbone of the model peptides derived from serine and threonine. Consequently, this type of glycosylation is responsible for the experimentally observed shift from extended conformations (mo

Thio acid/azide amidation: An improved route to N-acyl sulfonamides

A one-pot procedure for the conversion of carboxylic acids to N-acyl sulfonamides, via thio acid/azide amidation, is presented. The method is compatible with acid- and base-sensitive amino acid protection. N-Acyl sulfonamide synthesis on solid support, pe

INHIBITORS OF ANTHRAX LETHAL FACTOR

Methods, compounds and compositions for preventing and treating anthrax infections by inhibiting Anthrax Lethal Factor (LF) activity.

Bio-orthogonal affinity purification of direct kinase substrates

Protein phosphorylation is a major mechanism of post-translational protein modification used to control cellular signaling. A challenge in phosphoproteomics is to identify the direct substrates of each protein kinase. Herein, we describe a chemical strate

Total synthesis of thiangazole

A method for total synthesis of thiangazole (1), a tris-thiazoline- oxazole metabolite, is described. The key intermediate 9, a linear tetrapeptide amide composed of three S-benzyl-2-methylcysteine residues and a O-benzyl-threonine amide, was synthesized in 4 steps using 2-chloro-1,3- dimethyl-imidazolidium hexafluorophosphate(CIP)mediated activation. The successive thiazoline/oxazole rings were constructed by TiCl4mediated cycledehydration followed by acid-catalyzed Robinson-Gabriel reaction without difficulty.

Synthesis and Structure of Cyclic Phosphopeptides Containing a Phosphodiester Linkage

The synthesis of three cyclic phosphopeptides, which contain a phosphodiester linkage, is described.Starting from either Boc-L-Ser(OBn)-OH or Boc-L-Thr(OBn)-OH, three precursors for the macrocyclization by phosphitylation were prepared.After phosphitylati