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24985-85-1

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24985-85-1 Usage

Uses

Ethyl 5-hydroxyindole-2-carboxylate is used as an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.

Check Digit Verification of cas no

The CAS Registry Mumber 24985-85-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,9,8 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 24985-85:
(7*2)+(6*4)+(5*9)+(4*8)+(3*5)+(2*8)+(1*5)=151
151 % 10 = 1
So 24985-85-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO/c15-11-13-7-4-8-14(10-13)9-12-5-2-1-3-6-12/h1-3,5-6,13,15H,4,7-11H2

24985-85-1 Well-known Company Product Price

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  • Alfa Aesar

  • (L00774)  Ethyl 5-hydroxyindole-2-carboxylate, 98+%   

  • 24985-85-1

  • 250mg

  • 590.0CNY

  • Detail
  • Alfa Aesar

  • (L00774)  Ethyl 5-hydroxyindole-2-carboxylate, 98+%   

  • 24985-85-1

  • 1g

  • 1610.0CNY

  • Detail
  • Alfa Aesar

  • (L00774)  Ethyl 5-hydroxyindole-2-carboxylate, 98+%   

  • 24985-85-1

  • 5g

  • 6436.0CNY

  • Detail

24985-85-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 5-hydroxy-1H-indole-2-carboxylate

1.2 Other means of identification

Product number -
Other names 1H-Indole-2-carboxylic acid,5-hydroxy-,ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24985-85-1 SDS

24985-85-1Relevant articles and documents

AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND PREPARATION METHOD AND APPLICATION OF AROMATIC RING DERIVATIVE

-

, (2021/10/15)

Relating to a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, and an application of the compound as an S1P1 agonist.

Synthesis method for preparing 2-substituted indole derivative

-

Paragraph 0071-0074, (2019/05/28)

The invention relates to a synthesis method for preparing a 2-substituted indole derivative. The method includes the following steps: mixing aromatic amine compounds (I), ketone compounds (II) and a drying agent in an organic solvent; adding a palladium catalyst; and reacting in an aerobic weak acid environment to prepare the indole compounds (III). (I), (II) and (III) are as shown in the specification, wherein R1 is selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted phenyl, pyridyl and heterocyclic aryl; (I) can be pyridylamine, pyrimidylamine, pyridazinam or pyrazinamide which may further be substituted or unsubstituted; and the substituents are selected fromone or more C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, hydroxyl, amino; and R2 is selected from C1-C6 alkyl, formate groups or C1-C6 alkylamide groups.

Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy

Tercel, Moana,Lee, Ho H.,Mehta, Sunali Y.,Youte Tendoung, Jean-Jacques,Bai, Sally Y.,Liyanage, H. D. Sarath,Pruijn, Frederik B.

, p. 5834 - 5856 (2017/07/22)

A new series of nitro analogues of the duocarmycins was prepared and evaluated for hypoxia-selective anticancer activity. The compounds incorporate 13 different amine-containing side chains designed to bind in the minor groove of DNA while spanning a wide range of base strength from pKa 9.64 to 5.24. The most favorable in vitro properties were associated with strongly basic side chains, but the greatest in vivo antitumor activity was found for compounds containing a weakly basic morpholine. This applies to single-agent activity and for activity in combination with irradiation or chemotherapy (gemcitabine or docetaxel). In combination with a single dose of γ irradiation 50 at 42 μmol/kg eliminated detectable clonogens in some SiHa cervical carcinoma xenografts, and in combination with gemcitabine using a well-tolerated multidose schedule, the same compound caused regression of all treated A2780 ovarian tumor xenografts. In the latter experiment, three of seven animals receiving the combination treatment were completely tumor free at day 100.

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