50630-45-0Relevant academic research and scientific papers
THE IMPROVED SYNTHESIS OF 7-OXYGENATED INDOLES BY FISCHER INDOLIZATION AND ITS APPLICATION TO THE FIRST TOTAL SYNTHESIS OF EUDISTOMIDIN-A
Murakami, Yasuoki,Takahashi, Hiroyuki,Nakazawa, Yoshie,Koshimizu, Michie,Watanabe, Toshiko,Yokoyama, Yuusaku
, p. 2099 - 2100 (1989)
The Fischer indolization of o-sulfonyloxyphenylhydrazones 2b, c was found to give corresponding 7-oxygenated indoles 3 in moderate yields.This method was applied to the first total synthesis of eudistomidin-A 1.
Fischer indolization of 2-sulfonyloxyphenylhydrazones: A new and practical approach for preparing 7-oxygenated indoles and application to the first synthesis of eudistomidin-A. (Fischer indolization and its related compounds. Part 28)
Murakami, Yasuoki,Watanabe, Toshiko,Takahashi, Hiroyuki,Yokoo, Hiroshi,Nakazawa, Yoshie,Koshimizu, Michie,Adachi, Nori,Kurita, Masami,Yoshino, Tomoko,Inagaki, Takayuki,Ohishi, Maki,Watanabe, Mari,Tani, Masanobu,Yokoyama, Yuusaku
, p. 45 - 64 (2007/10/03)
An efficient method for synthesis of 7-oxygenated indoles was established by Fischer indolization of the phenylhydrazones (10) with a sulfonyloxy group at the ortho-position. This method was applied to the first synthesis of the calmodulin antagonist eudistomidin-A (2).
