249889-64-3 Usage
Uses
Used in Pharmaceutical Research:
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA is used as a research compound for studying the orexin 1 (OX1) receptor. Its high OX1/OX2 selectivity and bioavailability make it an important ligand in understanding the role of the orexin system in various physiological processes and potential therapeutic applications.
Used in Neuroscience Applications:
In the field of neuroscience, N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA is used as a selective antagonist for investigating the orexin system's involvement in sleep-wake regulation, addiction, and other neurobiological processes. N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA helps researchers explore the potential of targeting the orexin system for the development of novel treatments for sleep disorders, addiction, and other related conditions.
Used in Drug Development:
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA is also used in the development of new drugs targeting the orexin system. Its high selectivity for the OX1 receptor makes it a promising starting point for designing more potent and selective antagonists that could be used in the treatment of various disorders, including sleep-wake disorders and addiction.
Biological Activity
Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .
references
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.
Check Digit Verification of cas no
The CAS Registry Mumber 249889-64-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,9,8,8 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 249889-64:
(8*2)+(7*4)+(6*9)+(5*8)+(4*8)+(3*9)+(2*6)+(1*4)=213
213 % 10 = 3
So 249889-64-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)
249889-64-3Relevant academic research and scientific papers
ANTIANXIETY DRUGS AND A METHOD OF SCREENING THE SAME
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Page/Page column 20, (2008/06/13)
An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.
