249889-64-3

Basic information

• Product Name: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
• Synonyms: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;SB 334867;Zinc00008794;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride);SB334867 HCl
• CAS NO: 249889-64-3
• Molecular Formula: C₁₈H₁₄N₄O₂*ClH
• Molecular Weight: 319.32
• EINECS: 604-604-1
• Product Categories: Orexin receptor
• Mol File: 249889-64-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 450.5°C at 760 mmHg
• Flash Point: 226.2°C
• Appearance: /
• Density: 1.472g/cm³
• Vapor Pressure: 2.63E-08mmHg at 25°C
• Refractive Index: 1.793
• Storage Temp.: Desiccate at RT
• Solubility: Dichloromethane (Slightly), DMSO (Slightly)
• CAS DataBase Reference: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA(249889-64-3)
• EPA Substance Registry System: N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA(249889-64-3)

Safety Data

• Hazardous Substances Data: 249889-64-3(Hazardous Substances Data)

Usage

Uses

SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .

references

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

InChI:InChI=1/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)

Relevant articles and documents

ANTIANXIETY DRUGS AND A METHOD OF SCREENING THE SAME

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.