24993-90-6Relevant academic research and scientific papers
Carbonylative Suzuki-Miyaura coupling catalyzed by palladium supported on aminopropyl polymethylsiloxane microspheres under atmospheric pressure of CO
Zawartka, Wojciech,Po?piech, Piotr,Cypryk, Marek,Trzeciak, Anna M.
, p. 76 - 80 (2016)
Carbonylative Suzuki-Miyaura cross-coupling reactions of various aryl iodides with phenylboronic acids were catalyzed by palladium supported on amino-modified silica microspheres. Reactions performed with a very low concentration of Pd, under the atmospheric pressure of CO, led to high/moderate yields of multiple benzophenones.
Carbonylative Suzuki Coupling Reaction Catalyzed by a Hydrospirophosphorane Palladium Complex
Wójcik, Przemys?aw,Sygellou, Labrini,Gniewek, Andrzej,Skar?yńska, Anna,Trzeciak, Anna
, p. 4397 - 4409 (2017/11/21)
A Pd complex with the H-spirophosphorane ligand, PdCl2{P(OCMe2CMe2O)OC6H4NH2} (Cat. 1), was used as the catalyst in the carbonylative Suzuki coupling of substituted iodobenzenes with arylboronic acids and with sodium tetraphenylborate. Substituted diarylketones were obtained in good to excellent yields and a selectivity over 95 % under 1 atm of CO with 1.5 mol % of the catalyst. The promoting role of the H-spirophosphorane ligand in the catalytic process was evidenced. We used X-ray photoelectron spectroscopy, TEM, and 31P NMR spectroscopy to reveal that during the reaction Cat. 1 undergoes transformation into Pd complexes that bear the spirophosphorane ligand or other P ligands formed by its dealkylation and to Pd nanoparticles. All these Pd species contribute to the high productivity of the system.
A general synthesis of diarylketones by means of a three-component cross-coupling of aryl and heteroaryl bromides, carbon monoxide, and boronic acids
Neumann, Helfried,Brennfuehrer, Anne,Beller, Matthias
experimental part, p. 3645 - 3652 (2009/04/11)
Pd(OAc)2/di-1-adamantyl-n-butylphosphine (cataCXium A) is highly active in the three-component Suzuki carbonylation and represents the most general catalyst system reported up to now. A broad range of aryl/heteroaryl bromides and aryl boronic acids can be coupled to the corresponding diarylketones at low catalyst loadings.
An efficient and practical sequential one-pot synthesis of suprofen, ketoprofen and other 2-arylpropionic acids
Neumann, Helfried,Brennfuehrer, Anne,Beller, Matthias
experimental part, p. 2437 - 2442 (2009/10/06)
A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.
