249930-46-9Relevant academic research and scientific papers
4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
-
, (2020/07/05)
Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.
COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
-
, (2017/09/15)
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
Stereoselective total synthesis of (±)-fragranol by TiCl4 promoted [2 + 2] cycloaddition of allyl-tert-butyldiphenylsilane and methyl methacrylate
Knoelker, Hans-Joachim,Baum, Gerhard,Schmitt, Oliver,Wanzl, Guenter
, p. 1737 - 1738 (2007/10/03)
A stereoselective total synthesis of the monoterpenoid alcohol (±)-fragranol has been accomplished utilizing a TiCl4 promoted [2 ± 2] cycloaddition of allyl-tert-butyldiphenylsilane and methyl methacrylate as the key step.
