24997-88-4

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 27160-08-3 2-(3,4-dimethoxyphenyl)-ethylchloride 

Downstream Products

• 16240-59-8 4,4'-(3-aza-pentanediyl)-di-pyrocatechol 
• 75636-70-3 bis-N-<2-(3,4-dimethoxyphenyl)ethyl>trifluoroacetamide 

Relevant academic research and scientific papers

Trapping of iminiums by the indole nucleus during catalytic hydrogenation of nitriles: A rapid synthesis of tetrahydro-β-carbolines

Reductive self-condensation of indole acetonitrile upon catalytic hydrogenation over Pd·C in acetic acid yielded 1-(3-indolylmethyl)-1,2,3,4-tetrahydro-β-carboline. Hydrogenating 3,4-dimethoxyphenylacetonitrile failed to give tetrahydropapaverine, but a cross reaction between indole acetonitrile and 3,4-dimethoxyphenylacetonitrile allowed isolation of 1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-β-carboline, which was otherwise prepared (76%) by catalytic hydrogenation of a mixture of tryptamine and 3,4-dimethoxyphenylacetonitrile. Besides an easy access to the yohimbane skeleton, the reaction opens the way to a useful general synthesis of tetrahydro-β-carbolines.

Compounds having calcium blocking activity

Compound of general formula I STR1 and its addition salts with a pharmaceutically acceptable acid is described. The compound is prepared by reacting bis-(2-(3,4-dimethoxy-phenyl)ethyl)amine with formaldehyde in a reducing medium. The compound is effective in the treatment of cardiovascular diseases and disturbances in cerebral circulation.