25001-57-4

Basic information

• Product Name: justicidin A
• Synonyms: justicidin A;4,6,7-Trimethoxy-9-[3,4-(me;4,6,7-Trimethoxy-9-(1,3-benzodioxol-5-yl)naphtho[2,3-c]furan-1(3H)-one
• CAS NO: 25001-57-4
• Molecular Formula: C22H18O7
• Molecular Weight: 394.37
• Mol File: 25001-57-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 263°
• Boiling Point: 644.5°Cat760mmHg
• Flash Point: 282.4°C
• Appearance: /
• Density: 1.366g/cm³
• Vapor Pressure: 1.69E-16mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: justicidin A(CAS DataBase Reference)
• NIST Chemistry Reference: justicidin A(25001-57-4)
• EPA Substance Registry System: justicidin A(25001-57-4)

Safety Data

• Hazardous Substances Data: 25001-57-4(Hazardous Substances Data)

Usage

General Description

Justicidin A is a natural product and a member of the justicidin family of chemicals. It is found in the plant Justicia procumbens and has been shown to have potential pharmacological activity as an anti-inflammatory agent. Justicidin A has also been researched for its cytotoxic and anti-tumor properties, making it a potential candidate for cancer therapy. Additionally, its ability to inhibit inflammatory processes suggests it may have potential in the treatment of inflammatory conditions. Studies have shown that justicidin A can modulate the production of cytokines and suppress the activation of NF-κB, a key regulator of the immune response. As a result, this compound has garnered attention for its potential therapeutic use in the treatment of various diseases and conditions.

InChI:InChI=1/C22H18O7/c1-24-16-7-12-13(8-17(16)25-2)21(26-3)14-9-27-22(23)20(14)19(12)11-4-5-15-18(6-11)29-10-28-15/h4-8H,9-10H2,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 22055-22-7 diphyllin 
• 74-88-4 methyl iodide 
• 58-55-9 theophylline 
• 16900-54-2 3-(3,4-methylenedioxyphenyl)propynoic acid ethyl ester 
• 4687-37-0 ethyl 3,4-dimethoxybenzoylacetate 
• 120-57-0 piperonal 
• 497-23-4 2-buten-4-olide 
• 50766-67-1 2-(3,4-dimethoxyphenyl)-1,3-dithiane 
• 74-83-9 methyl bromide 
• 1621253-11-9 9-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl t-butylcarbonate 
• 1621253-10-8 9-[(tert-butoxycarbonyl)oxy]-6,7-dimethoxy-3-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl trifluoromethanesulfonate 
• 1621253-09-5 tert-butyl (9-hydroxy-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl)carbonate 
• 113232-81-8 5,6-dimethoxy-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile 

Relevant articles and documents

Total synthesis of (±)-justicidin P. A new lignan lactone from Justicia extensa

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Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius

The arylnaphthalide lignan glycosides, taxodiifoloside (1), cleistanthoside A (2), cleistanthin A (3) and cleistanthin A methyl ether (4), together with a triterpene, glochidone (5), have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods. Compounds 3 and 4, as well as the derivatives 2a and 3a exhibited potent cytotoxic activities with GI50 values in the range of 10-7-10-9 M in five cultured mammalian cancer cell lines while the new compound 1 showed moderate activity (GI50 in the order of 10-6 M). Compounds 2 and 5 were inactive in all tested cell lines. Georg Thieme Verlag KG Stuttgart.

Patentiflorin A Analogs as Antiviral Agents

The present disclosure relates to patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.

An Optimized and General Synthetic Strategy To Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides

A simple method for the preparation of arylnaphthalene lactone natural products was developed and used to synthesize diphyllin (10), justicidin A (12), cilinaphthalide B (13), taiwanin E (15), chinensinaphthol (16), taiwanin E methyl ether (17), chinensin