4687-37-0

Basic information

• Product Name: 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;ETHYL 3-(3,4-DIMETHOXYPHENYL)-3-OXOPROPANOATE;ETHYL 3,4-DIMETHOXYBENZOYLACETATE;Ethyl 3,4-diMethoxybenzoylacetate 97%;Ethyl 3-oxo-3-(3,4-dimethoxyphenyl)propanoate;Ethyl veratroylacetate
• CAS NO: 4687-37-0
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.26
• Product Categories: C12 to C63;Carbonyl Compounds;Esters
• Mol File: 4687-37-0.mol
• Article Data: 35

Chemical Properties

• Melting Point: 37-41 °C(lit.)
• Boiling Point: 350.9 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 4.27E-05mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.77±0.48(Predicted)
• CAS DataBase Reference: 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(4687-37-0)
• EPA Substance Registry System: 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(4687-37-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 4687-37-0(Hazardous Substances Data)

Usage

General Description

3-(3,4-Dimethoxy-phenyl)-3-oxo-propionic acid ethyl ester, also known as ethyl 3-(3,4-dimethoxyphenyl)-3-oxopropanoate, is a chemical compound with the molecular formula C13H16O5. It is an ethyl ester derivative of 3-(3,4-dimethoxyphenyl)-3-oxopropanoic acid, and it is commonly used in organic synthesis and pharmaceutical research. 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is a white solid with a molecular weight of 248.26 g/mol. Its precise applications and properties are dependent on the specific chemistry and intended usage, but it may be used as an intermediate in the synthesis of other compounds or as a reagent in various chemical reactions.

InChI:InChI=1/C13H16O5/c1-4-18-13(15)8-10(14)9-5-6-11(16-2)12(7-9)17-3/h5-7H,4,8H2,1-3H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-07-2 Veratric acid 
• 141-78-6 ethyl acetate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 2859-78-1 4-Bromoveratrole 
• 6148-64-7 ethyl potassium malonate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 851-36-5 diethyl (3,4-dimethoxybenzoyl)malonate 
• 141-97-9 ethyl acetoacetate 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 944329-82-2 C₂₆H₂₈O₁₀ 
• 1374639-85-6 ethyl 2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 4676-33-9 3,4-dimethyl-2,5-bis(3,4-dimethoxyphenyl)furan 
• 4687-31-4 2,5-bis-(3,4-dimethoxy-phenyl)-3,4-bis-hydroxymethyl-furan 
• 4687-44-9 2,5-bis-(3,4-dimethoxy-phenyl)-furan-3,4-dicarboxylic acid diethyl ester 
• 1026555-96-3 4-Benzo[1,3]dioxol-5-yl-2-(3,4-dimethoxy-phenyl)-1-(2-propylamino-ethyl)-pyrrolidine-3-carboxylic acid ethyl ester 
• 207272-63-7 2-Benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-furan-3,4-dicarboxylic acid diethyl ester 
• 207272-65-9 [2-Benzo[1,3]dioxol-5-yl-5-(3,4-dimethoxy-phenyl)-4-hydroxymethyl-furan-3-yl]-methanol 

Relevant articles and documents

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles

An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition,

Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters

We report herein an Ir-catalyzed intermolecular amino group transfer to β-keto esters (amides) to access α-aminocarbonyl products with excellent chemoselectivity. The key strategy was to engineer electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.

COMPOUNDS FOR TREATING DIABETES AND/OR RELATED CONDITIONS

Compounds useful for treating or preventing diabetes and related conditions, and for preventing, inhibiting or reversing amylin-amyloid fibril formation, preventing islets of Langerhans (Beta)-cell death, preventing or reversing the transition from soluble human amylin to insoluble human amylin, preventing and inhibiting or reversing cytotoxic amylin fibril formation. The invention relates to compounds of Formula (I) and compounds of Formula (II): (Formulae (I) and (II)).