4687-37-0

Usage

Uses

Used in Organic Synthesis:
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as an intermediate for the synthesis of various organic compounds, facilitating the creation of a range of chemical products due to its reactive functional groups.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a reagent in chemical reactions that contribute to the development of new pharmaceuticals, potentially aiding in the discovery of novel therapeutic agents.
Used in Chemical Reactions:
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is employed as a reagent in a variety of chemical reactions, leveraging its chemical properties to participate in the formation of new compounds or the modification of existing ones.

InChI:InChI=1/C13H16O5/c1-4-18-13(15)8-10(14)9-5-6-11(16-2)12(7-9)17-3/h5-7H,4,8H2,1-3H3

Upstream product

• 76787-81-0 3-oxo-2-veratroyl-butyric acid ethyl ester 
• 3943-77-9 ethyl veratrate 
• 141-78-6 ethyl acetate 
• 141-97-9 ethyl acetoacetate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 623-73-4 diazoacetic acid ethyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 851-36-5 diethyl (3,4-dimethoxybenzoyl)malonate 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 2859-78-1 4-Bromoveratrole 
• 6148-64-7 ethyl potassium malonate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 93-07-2 Veratric acid 

Downstream Products

• 70460-22-9 2-(3,4-dimethoxy-phenyl)-5-hydroxy-7-methyl-chromen-4-one 
• 15236-03-0 2-(3,4-dimethoxylphenyl)-7-hydroxy-5-methyl-4-oxo-4H-chromene 
• 4712-12-3 5,7-dihydroxy-3',4'-dimethoxy flavone 
• 10544-05-5 2-(3,4-dimethoxy-phenyl)-7-hydroxy-5-methoxy-chromen-4-one 
• 29080-58-8 5-hydroxy-3',4',7-trimethoxyflavone 
• 23982-43-6 4-(3',4'-dimethoxyphenyl)-7-hydroxycoumarin 
• 854679-72-4 ethyl 3-(3,4-dimethoxyphenyl)-2-methyl-3-oxopropanoate 
• 133899-48-6 ethyl α-(5-bromopentyl)-3,4-dimethoxy-β-oxobenzenepropionate 
• 134567-94-5 5-(3,4-Dimethoxyphenyl)-4-ethoxycarbonyl-2,3-dioxo-2,3-dihydrofuran 
• 112778-60-6 (2S,3S)-2,5-Bis-(3,4-dimethoxy-phenyl)-2,3-dihydro-furan-3,4-dicarboxylic acid diethyl ester 
• 112797-25-8 (4R,5S)-4-Acetoxymethyl-2,5-bis-(3,4-dimethoxy-phenyl)-4,5-dihydro-furan-3-carboxylic acid ethyl ester 
• 81581-29-5 erythro-diethyl 2,3-bis-(3,4-dimethoxybenzoyl)butane-1,4-dioate 
• 4687-40-5 threo-diethyl 2,3-bis-(3,4-dimethoxybenzoyl)butane-1,4-dioate 
• 4687-40-5 diethyl 2,3-bis-(3,4-dimethoxybenzoyl)butane-1,4-dioate 

Relevant academic research and scientific papers

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles

An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition,

Construction of isoxazolone-fused phenanthridinesviaRh-catalyzed cascade C-H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones

A Rh(iii)-catalyzed cascade C-H activation/intramolecular cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons. The protocol features the simultaneous one-pot formation of two new C-C/C-N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It is amenable to large-scale synthesis and further transformation.

Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters

We report herein an Ir-catalyzed intermolecular amino group transfer to β-keto esters (amides) to access α-aminocarbonyl products with excellent chemoselectivity. The key strategy was to engineer electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.

Compound for treating diabetes and/or related disorders

The invention discloses a compound for treating diabetes and/or related disorders, specifically a method for preventing, inhibiting and/or reversing amylin amyloid fibril formation, preventing isletsof Langerhans beta-cell death, preventing and/or reversing conversion of soluble human amylin to insoluble human amylin, and preventing and inhibiting and/or reversing cytotoxic amylin fibril formation. The invention also relates to a compound for preparing drugs for preventing and/or treating amylin amyloid-associated diseases.

COMPOUNDS FOR TREATING DIABETES AND/OR RELATED CONDITIONS

Compounds useful for treating or preventing diabetes and related conditions, and for preventing, inhibiting or reversing amylin-amyloid fibril formation, preventing islets of Langerhans (Beta)-cell death, preventing or reversing the transition from soluble human amylin to insoluble human amylin, preventing and inhibiting or reversing cytotoxic amylin fibril formation. The invention relates to compounds of Formula (I) and compounds of Formula (II): (Formulae (I) and (II)).

A orange flavone synthesis method (by machine translation)

The invention provides a method for synthesis of orange flavone, solve the existing orange flavone can only be from natural plant obtained by the separation, yield is relatively low, the problem of high cost. The invention first of all by the 3, 4 - dimet

Rate Enhancement in CAN-Promoted Pd(PPh3)2Cl2-Catalyzed Oxidative Cyclization: Synthesis of 2-Ketofuran-4-carboxylate Esters

Stoichiometric ceric ammonium nitrate (CAN) and a catalytic amount of Pd(PPh3)2Cl2 (5 mol %) can rapidly produce multisubstituted 2-ketofuran-4-carboxylate esters from 2-propargylic 1,3-ketoesters via oxidative O-cyclization reaction. Pd(PPh3)2Cl2 was found to be the crucial catalyst as its inclusion greatly enhanced the rate of the reaction and cleanly afforded the products within minutes. Over 30 substrates were successfully converted to the desired compounds in mostly moderate to good yields.

Substituted phenyl pyrazolone derivatives and preparation and application (by machine translation)

The present invention provides a substituted phenyl pyrazolone derivatives, in particular to a 2 - phenyl - pyrazoline - 3 - ketone compound and its pharmaceutically acceptable salt, solvate. The substituted acetic acid ethyl ester with sodium hydroxide in aqueous solution in the [...] reflux reaction, then in the palladium-carbon and hydrogen under the action of the hydrogenolysis benzyl, phenyl [...] obtained, with the bromochlorodifluoromethane alkane reaction to obtain the chloro, finally with the secondary amine on the condensation to obtain the target compound. The invention substituted phenyl pyrazoline compounds in vitro exhibits excellent capability of eliminating the free radicals, and have more strongly inhibit H3 receptor activity, exhibits excellent penetration of the blood brain barrier capacity, has a unique dual active, therefore, its for cerebral apoplexy, Alzheimer's disease, Parkinson's disease, progressive neurodegenerative diseases such as frozen sickness treatment has a unique clinical effect. The compound of the invention for treating central system system related disease and inflammatory disease application of the medicament. The formula structure is as follows: (by machine translation)

Investigate cleavage of β-O-4 linkage in lignin model compounds by aerobic oxidation of Cα and Cγ hydroxyl groups

The selective cleavage of common linkages in lignin polymers is a promising approach to generate valuable aromatic hydrocarbons. Herein, we found that on oxidation of Cα and Cγ hydroxyl groups in β-O-4 lignin model compounds with TEMPO catalyst resulted in the formation of 1,3-dicarbonyl TEMPO adduct. These oxidized products readily underwent fragmentation at Cα-Cβ bond in the presence of a catalytic amount of acid to generate corresponding carboxylic acid and phenol monomers.

Selective cleavage of the Cα-Cβ linkage in lignin model compounds via Baeyer-Villiger oxidation

Lignin is an amorphous aromatic polymer derived from plants and is a potential source of fuels and bulk chemicals. Herein, we present a survey of reagents for selective stepwise oxidation of lignin model compounds. Specifically, we have targeted the oxidative cleavage of Cα-Cβ bonds as a means to depolymerize lignin and obtain useful aromatic compounds. In this work, we prepared several lignin model compounds that possess structures, characteristic reactivity, and linkages closely related to the parent lignin polymer. We observed that selective oxidation of benzylic hydroxyl groups, followed by Baeyer-Villiger oxidation of the resulting ketones, successfully cleaves the Cα-Cβ linkage in these model compounds. This journal is