2501-37-3

Usage

InChI:InChI=1/C10H11NO2/c1-13-10-4-2-9(3-5-10)6-7-11-8-12/h2-8H,1H3,(H,11,12)

Upstream product

• 175089-69-7 N-<2-(p-methoxyphenyl)-2-(phenylthio)-ethyl>-formamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 113934-91-1 2-(p-methoxyphenyl)-2-(phenylthio)-1-aminoethane 
• 52809-71-9 (1-(4-methoxyphenyl)-2-nitroethyl) phenyl sulfide 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 175089-70-0 N-<2-(p-methoxyphenyl)-2-(phenylsulfoxy)-ethyl>-formamide 
• 77287-34-4 formamide 
• 41003-94-5 diethyl isocyanomethylphosphonate 
• 60-18-4 L-tyrosine 

Relevant academic research and scientific papers

Reactions of 1-acylamino-1-(trimethylsiloxy)alkanes: Versatile precursors to acylimines

1-Acylamino-1-(trimethylsiloxy)alkanes react with carbon and heteroatom nucleophiles to give the corresponding 1-substituted-1-acylaminoalkanes. The 1-acylamino-1-(trimethylsiloxy)alkanes can also give rise to enamides, and by this route the mild antibiotic tuberin, and the isomeric (Z)-tuberin have been prepared. A further example of their reactions is illustrated with the acid-catalysed intramolecular cyclisation onto a carbon-carbon double bond. These transformations show that 1-acylamino-1-(trimethylsiloxy)alkanes are versatile precursors to synthetically useful acylimines.

Total synthesis of erbstatin analogs

The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) STR1 wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n is an integer of 1 to 3; A is --CH=CH-- or --CH2 --CH2 --; R1 is hydrogen or a lower alkyl group, and R2 is a hydrogen or halogen atom.

BIOSYNTHESIS OF TUBERIN AND XANTHOCILLIN FROM TYROSINE

(2S)-Tyrosine (5) is incorporated stereospecifically into tuberin (1) with retention of the 3-pro-S proton and incomplete retention of the 2-S proton; a parallel pathway to the xanthocillin (4) is apparent with stereospecific retention of the 3-pro-R proton of tyrosine; results of experiments with threo- and erythro-3-hydroxytyrosine in relation to tuberin biosynthesis are reported.