250135-50-3

Upstream product

• 100-39-0 benzyl bromide 
• 218943-31-8 (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid 
• 193148-60-6 tert-butyl N-{(1S)-[(benzyloxy)methyl]-3-diazo-2-oxopropyl}carbamate 
• 66866-45-3 C₂₀H₂₉NO₇ 
• 23680-31-1 BOC-O-benzyl-L-serine 

Downstream Products

• 250135-63-8 (R)-4-Benzyloxymethyl-1-triisopropylsilanyl-azetidin-2-one 
• 250135-52-5 (4R)-4-(benzyloxymethyl)azetidin-2-one 
• 250135-62-7 (R)-3-Amino-4-benzyloxy-butyric acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

A series of monobactam inhibitors of HCMV (N(o)) protease bearing a heterocycle linked by a methylene group at C-4 is described. Inhibitors containing a heterocycle such as a 2-furyl, 2-thiophenyl, 4-methyl-2-tetrazole and 2-benzothiazole were found to be active in a plaque reduction assay. Furthermore, 2-benzothiazole derivatives were shown to inhibit the HCMV protease activity inside cells by using a cell transfection assay, indicating that their antiviral activity in the plaque reduction assay could be attributed to protease inhibition. Copyright (C) 1999 Elsevier Science Ltd.