25016-12-0 Usage
Uses
Used in Pharmaceutical Industry:
1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE serves as a valuable starting material for the preparation of a wide range of chemical compounds, including those with potential applications in materials science, agrochemicals, and other specialty chemicals.
Used in the Preparation of SARM1 Inhibitors:
1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE is used as a crucial component in the development of inhibitors targeting the SARM1 protein. These inhibitors are designed for the treatment or prevention of axonal degeneration, a process that can lead to the loss of nerve function and various neurodegenerative diseases. By targeting SARM1, these inhibitors may help protect neurons and preserve their function, offering potential therapeutic benefits for patients suffering from conditions such as multiple sclerosis, Alzheimer's disease, and other axonal degeneration-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 25016-12-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,0,1 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25016-12:
(7*2)+(6*5)+(5*0)+(4*1)+(3*6)+(2*1)+(1*2)=70
70 % 10 = 0
So 25016-12-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O/c1-5-6(4-9)3-8(2)7-5/h3-4H,1-2H3
25016-12-0Relevant academic research and scientific papers
Method for synthesizing 1,3-dimethyl-1H-pyrazole-4-carboxylic acid
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Paragraph 0020; 0035; 0038; 0052-0057, (2019/11/12)
The invention relates to a method for synthesizing 1,3-dimethyl-1H-pyrazole-4-carboxylic acid. The method comprises the step that 1,3-dimethyl-1H-pyrazole-4-carboxylic acid is prepared from the raw material: ethyl acetoacetate through condensation and ring closure, formylation, reductive dechlorination and oxidation. Compared with an existing method, the method has lower reaction cost, a higher yield and better economic performance; and the problems such as cost and environmental pollution caused by heavy metal oxidation are solved, and conditions are created for industrialization.
Introduction of N-containing heterocycles into pyrazole by nucleophilic aromatic substitution
Park, Min-Sup,Park, Hyun-Ja,Park, Koon Ha,Lee, Kee-In
, p. 1541 - 1550 (2007/10/03)
The nucleophilic aromatic substitution on 5-chloropyrazoles activated by the electron-withdrawing formyl group offers a useful method to introduce a wide range of N-containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N-1 substitution.
