25018-29-5

Upstream product

• 3615-47-2 O²,O³,O⁴,O⁶-Tetramethyl-D-idose 
• 3615-47-2 2,3,4,6-tetra-O-methyl-D-glucose 
• 99-20-7 TREHALOSE 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 35311-28-5 methyl-(tetra-O-methyl-β-D-idopyranoside) 
• 1195330-79-0 methyl-(O²,O⁴,O⁶-trimethyl-β-D-idopyranoside) 
• 74-83-9 methyl bromide 
• 25018-27-3 trehalose octaacetate 

Relevant academic research and scientific papers

Identification of fungal trehalose for the diagnosis of invasive candidiasis by mass spectrometry

The rapidity of the diagnosis of invasive candidiasis (IC) is crucial to allow the early introduction of antifungal therapy that dramatically increases the survival rate of patients. Early diagnosis is unfortunately often delayed because Candida blood culture, the gold standard diagnostic test, is positive in only 50% of cases of IC and takes several days to obtain this result. Complementary non-culture-based methods relying on the detection of Candida cell wall polysaccharides in the serum, β-glucans and mannans, by enzymatic and immunological reagents have been successfully developed to allow a more efficient patients care. We have previously demonstrated that detection of circulating glycans by mass spectrometry could provide a reliable and cost-effective early diagnosis method called MS-DS for Mass Spectrometry of Di-Saccharide. Here, by comparing patient's sera and Candida albicans strains deficient in carbohydrates synthesis, we demonstrate that trehalose derived from fungal metabolism can be specifically targeted by MS-DS to allow early diagnosis. In particular, the use of C. albicans strains deficient in the synthesis of trehalose synthesizing enzymes Tps1 and Tps2 show that MS-DS results were correlated to the metabolism of trehalose. Finally, we demonstrate that the performance of the IC diagnosis can be significantly improved by using high resolution mass spectrometry, which opens new perspectives in the management of the disease.

Synthesis of sterically crowded derivatives of anomeric pairs of D-glucose disaccharides

Derivatization of carbohydrates is of considerable interest since the derivatives can be used for structural studies in the field of mass spectrometry. We report here the synthesis of a series of sterically crowded derivatives of various linkage and stere