250215-07-7

Upstream product

• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 100-52-7 benzaldehyde 

Downstream Products

• 125049-95-8 α-N-Cbz-δ-N-(Benzyloxy)-D-cycloornithine 
• 250215-11-3 N²-benzyloxycarbonyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine 
• 250215-09-9 C₂₀H₂₂N₂O₅ 
• 762227-03-2 N²-benzyloxycarbonyl-N⁵-hydroxy-L-ornithine 
• 250215-08-8 N²-benzyloxycarbonyl-N⁵-(3-phenyloxaziridinyl)-L-ornithine 

Relevant academic research and scientific papers

BACTERIAL SIDEROPHORE GRAMIBACTIN

The invention relates to a peptide siderophore, comprising one or more N-nitroso-hydroxylamine ligands. In a preferred embodiment, the peptide siderophore comprises two side chains, each with a N-nitroso-hydroxylamine ligand, and a further side chain with one or more hydroxy carboxylic acid, hydroxamate, catecholate and/or salicylate ligands, wherein the siderophore is preferably cyclic. The invention further relates to a bacterial cell expressing a peptide siderophore of the invention and a composition comprising a peptide siderophore of the invention, for example in the form of its corresponding iron-complex, or bacteria of the invention. The invention further relates to a method for promoting plant growth, promoting root growth or development, improving stress tolerance in a plant and/or for increasing crop yields of a plant, and/or for delivering nitric oxide (NO) to a plant and/or for enhancing chlorophyll production in a plant by administering the peptide siderophore, bacteria expressing the peptide siderophore or a composition comprising the peptide siderophore to said plant.

A 4-tert-butylcalix[4]arene tetrahydroxamate podand based on the 1-oxypiperidine-2-one (1,2-PIPO-) chelate. Self-assembly into a supramolecular ionophore driven by coordination of tetravalent zirconium or hafnium(iv)

An octadentate tetrahydroxamic calix[4]arene podand incorporating 1-hydroxypiperidine-2-one (1,2-PIPOH) binding units has been designed as a specific chelator for tetravalent metal cations like Zr4+ or Hf 4+. This receptor, which can be considered as the first ever abiotic ligand possessing only cyclic six-membered hydroxamate groups, has been synthesized and characterized in its tetraprotonated form (1H4). Contrary to expectation, however, this new chelator did not form a 1:1 complex upon reaction with M(acac)4 (M = Zr and Hf; acac = acetylacetonate), but rather self-assembled into a dimeric species of 2:2 stoichiometry. The latter could be characterized in solution by mass spectrometry and NMR spectroscopy as its monopotassium adduct ([M2K(1)2] +), pointing to the ionophoric character of the M2(1) 2 complex. This journal is the Partner Organisations 2014.

Practical synthesis of hydroxamate-derived siderophore components by an indirect oxidation method and syntheses of a DIG-siderophore conjugate and a biotin-siderophore conjugate

A practical large-scale synthesis of hydroxamate-derived siderophore components (30 and 40) that utilizes an efficient indirect oxidation method is described and applied to the syntheses of nonradioactive labeled siderophores. Oxidation of imines derived from L-ornithine (17) and its tripeptide (19) afforded oxaziridines that were isomerized to stable nitrones (16 and 18). Acid-catalyzed hydrolysis of nitrones provided hydroxylamines that were converted to the desired hydroxamic acids (30 and 40) suitable for constructing siderophore-drug conjugates (2). The entire synthetic sequence required no chromatographic separation. DIG- and biotin-labeled ferrichrome analogues designed to detect and isolate ferrichrome receptors in various microbes were also synthesized.