25023-22-7

Usage

Uses

Used in Pharmaceutical Synthesis:
IMIDAZOL-1-YL-ACETIC ACID METHYL ESTER serves as a key precursor in the pharmaceutical industry, utilized for the synthesis of various drugs. Its unique structure allows for the development of compounds with specific biological activities, contributing to the creation of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, IMIDAZOL-1-YL-ACETIC ACID METHYL ESTER is employed as a building block for designing and optimizing new molecules with desired pharmacological properties. Its presence in the molecular structure can influence the compound's interaction with biological targets, enhancing the effectiveness of potential drugs.
Used in Organic Chemistry Research:
IMIDAZOL-1-YL-ACETIC ACID METHYL ESTER is also widely used in organic chemistry research for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and functional groups make it a suitable candidate for various organic transformations, broadening the scope of chemical research.
Used in Chemical Industry:
The chemical industry leverages IMIDAZOL-1-YL-ACETIC ACID METHYL ESTER for the production of various organic compounds and intermediates. Its versatility and compatibility with different chemical processes make it a valuable component in the synthesis of specialty chemicals and materials.

InChI:InChI=1/C6H8N2O2/c1-10-6(9)4-8-3-2-7-5-8/h2-3,5H,4H2,1H3

Upstream product

• 96-34-4 methyl chloroacetate 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 288-32-4 1H-imidazole 
• 96-32-2 bromoacetic acid methyl ester 
• 6773-29-1 dimethyl diazomalonate 

Downstream Products

• 22884-10-2 imidazol-1-ylacetic acid 
• 1225209-30-2 C₂₇H₂₇N₃O₅ 

Relevant academic research and scientific papers

Hydroxyethyl and ester co-functionalized imidazolium iodide for highly efficient solid-state dye-sensitized solar cells

Hydroxyethyl and ester co-functionalized imidazolium iodide has been designed and synthesized as an efficient solid state electrolyte for dye-sensitized solar cells. Single crystal X-ray analyses confirm the presence of ordered three dimensional ionic channels for iodide, which exhibits high conductivity when mixed with iodine and LiI and achieves a power conversion efficiency of 7.45%.

Preparation method of imidazole and triazole compound intermediates

The invention belongs to the technical field of imidazole compound preparation, and particularly relates to a preparation method of imidazole and triazole compound intermediates. The preparation method comprises the steps of (1) stirring and mixing a comp

POSS with eight imidazolium iodide arms for efficient solid-state dye-sensitized solar cells

Polyhedral oligomeric silsesquioxane functionalized with eight imidazolium iodide arms has been designed and synthesized for use as solid-state electrolytes in solid-state dye-sensitized solar cells, which exhibits a power conversion efficiency of 7.11% under one sun illumination and good long-term stability under one sun soaking.

CEPHALOSPORIN HAVING CATECHOL GROUP

The present invention provides Cephem compounds which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria as follows: A compound of the formula: wherein, X is N, CH or C-Cl; T is S or the like; A and G are lower alkylene or the like; B is a single bond or the like; D is a single bond, -NR7-, -CO-, -CO-NR7-, -NR7-CO-, -NR7-CO-NR7-, or the like; E is optionally substituted lower alkylene; F is a single bond or optionally substituted phenylene; R3, R4, R5 and R6 each is independently hydrogen, halogene, nitrile, or the like; or an ester, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

Synthesis and fluorescent characteristics of imidazole-indocyanine green conjugates

We have successfully synthesized imidazole-dye conjugates by linking imidazole and nitroimidazoleacetic acids to an indocyanine green (ICG) carboxylic acid derivative, using an ethanolamine linker. These dye-conjugates show absorbance peaks at 754-756 nm and fluorescence peaks at 780 nm. The dye-conjugates show a blue shift of 25 nm and 30 nm in the absorption and fluorescence spectra respectively when compared to that of standard cardiogreen. There is no change in absorption and fluorescence spectral profiles between the ICG derivative and imidazole conjugates. The extinction coefficients of new ICG derivative and imidazole conjugates are 1.8 times higher than that of standard ICG. The relative quantum yields of the new compounds are 4.5-5.5 times higher than that of the Sigma-Aldrich's ICG. The dyes are tested for hypoxia in-vitro with 4T1 luc cell lines and it is found that the cells treated with 2-nitroimidazole ICG show a contrast of fluorescence signal of 2.5-3.0 for the cells under hypoxic to that of cells under normoxic. However pure ICG shows no significant difference between hypoxic and normoxic cells.

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors

A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the

Process for Making Zoledronic Acid

Processes for making zoledronic acid can be advantageously carried out in a solvent/diluent that comprises a mixture of (i) a polyalkylene glycol and (ii) a cyclic carbonate of the formula (3) wherein n is an integer from 2 to 4, and R1 and R2 each independently represent a hydrogen or a C1-C4 alkyl group.

Process for making zoledronic acid

The invention relates to a process a process, which comprises: reacting in a solvent/diluent a compound of formula (2) or a salt or ester thereof with a phosphonation agent to form phosphonated intermediates; and subsequently hydrolyzing said intermediates to form a compound of formula (1) or a salt or hydrate thereof wherein said solvent/diluent comprises a mixture of (i) a polyalkylene glycol and (ii) a cyclic carbonate of the formula (3) wherein n is an integer from 2 to 4, and R1 and R2 each independently represent a hydrogen or a C1-C4 alkyl group and to the use of intermediates therein.

N-alkylation of N-trimethylsilylimidazole

The reaction of N-trimethylsilylimidazole with alkyl chloroacetates is studied. This process yields a mixture of N-alkylation and quarternization products in the ratio dependent on the reaction conditions. The reaction mechanism is discussed. 1H NMR data show that high melting point and low solubility of 1-imidazolylacetic acid in organic solvents are evidently caused by the formation of strong intermolecular hydrogen bonds, whereas in water zwitterionic structures with the protonation of both nitrogen atoms are formed.

Benzoamide piperidine containing compounds and related compounds

The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.