250253-63-5

Upstream product

• 250253-66-8 C₂₇H₂₄BrNO₅ 
• 250253-69-1 (CH₃O)2(OC₇H₇)C₆HBrCHO 
• 19283-70-6 3,4-dimethoxysalicylaldehyde 
• 6527-13-5 3,4-dimethoxy-(phenylmethoxy)benzaldehyde 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 1059628-37-3 C₆H₄NO₅S^(1-)*C₂₈H₂₄NO₅⁽¹⁺⁾ 

Relevant academic research and scientific papers

A new synthetic approach to 7-hydroxynitidine

Benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized from readily available 2-benzyloxy-6-bromo-3,4-dimethoxybenzaldehyde 5 and napthylamine 6 using reductive amination followed by radical cyclization in eight steps. This method is highly e

Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.

[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The cytotoxic activity of this compound against HeLa S3 cells was strong, but not greater than those of its mother compounds, nitidine and NK109. We also synthesized other 9-oxygenated benzo[c]phenanthridine alkaloids, 7-methoxynitidine, 9-demethylnitidine, nitidine, and fagaronine, and tested their cytotoxic activities. These results suggest that the 7-hydroxy group enhances antitumor activity and an 8- or 9-hydroxy group weakens this activity.