6527-13-5

Basic information

• Product Name: 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE
• Synonyms: 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE
• CAS NO: 6527-13-5
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.3
• Mol File: 6527-13-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE(6527-13-5)
• EPA Substance Registry System: 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE(6527-13-5)

Safety Data

• Hazardous Substances Data: 6527-13-5(Hazardous Substances Data)

Usage

General Description

2-(Benzyloxy)-3,4-dimethoxybenzaldehyde, also known as 3,4-dimethoxybenzaldehyde-2-benzyloxy, is a chemical compound with the molecular formula C16H16O4. It is a pale yellow solid that is commonly used in organic synthesis and as a reagent in chemical reactions. 2-(BENZYLOXY)-3,4-DIMETHOXYBENZALDEHYDE contains a benzyl ether group and two methoxy groups attached to a benzene ring, as well as an aldehyde functional group. It is commonly utilized in the synthesis of various pharmaceuticals and other organic compounds due to its ability to undergo a variety of chemical reactions. Additionally, it has been studied for its potential anti-cancer and antimicrobial properties.

Upstream product

• 19283-70-6 3,4-dimethoxysalicylaldehyde 
• 1699-38-3 3-benzyloxy-4-methoxy-benzyl chloride 
• 100-44-7 benzyl chloride 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 75-52-5 nitromethane 
• 121-33-5 vanillin 
• 100-39-0 benzyl bromide 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 82835-33-4 2,3'-dibenzyloxy-2'-hydroxy-3,4,4'-trimethoxychalcone 
• 74614-84-9 <3,4-dimethoxy-2-(phenylmethoxy)phenyl>oxirane 
• 123796-57-6 (2-Benzyloxy-3,4-dimethoxy-phenyl)-methanol 
• 957785-27-2 (E)-3-[(3,4-dimethoxy-2-phenylmethoxy)phenyl]-1-[(5,6,8-trimethoxy)-2-quinolyl]-2-propen-1-one 
• 372101-93-4 8-amino-2-(3-amino4-hydroxyphenyl)-3-hydroxy-6-methyl-4H-chromen-4-one 
• 372102-24-4 (E)-3-[2-(benzyloxy)-3,4-dimethoxyphenyl]-1-(2-hydroxy-5-methylphenyl)-2-propen-1-one 
• 1262680-47-6 C₁₈H₂₀O₄ 
• 63110-80-5 N-<β-(2-Benzyloxy-3,4-dimethoxy-phenyl)-aethyl>-4-methoxy-phenylacetamid 
• 31435-02-6 N-[2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-ethyl]-2-(4-benzyloxy-phenyl)-acetamide 

Relevant articles and documents

Synthetic studies towards the penicisulfuranols: Synthesis of an advanced spirocyclic diketopiperazine intermediate

The 2,5-diketopiperazine (DKP) moiety is a core feature of many natural products and medicinally relevant scaffolds. As part of our efforts directed towards a total synthesis of penicisulfuranol B, we have developed and report herein: (1) the preparation of an N-hydroxy diketopiperazine intermediate accessible via a molybdenum-mediated oxidation of a parent diketopiperazine, and (2) further synthetic studies leading to a novel spirocyclic dihydrobenzofuran-containing diketopiperazine.

Total synthesis of streptonigrone

(Chemical Equation Presented) A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad-Limpach reaction, rather than the customary Friedlaender methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.

Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.

[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The cytotoxic activity of this compound against HeLa S3 cells was strong, but not greater than those of its mother compounds, nitidine and NK109. We also synthesized other 9-oxygenated benzo[c]phenanthridine alkaloids, 7-methoxynitidine, 9-demethylnitidine, nitidine, and fagaronine, and tested their cytotoxic activities. These results suggest that the 7-hydroxy group enhances antitumor activity and an 8- or 9-hydroxy group weakens this activity.