250261-54-2

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 250261-53-1 N-(Cyclohex-1-enyl)-N-(4-methoxybenzyl)-2-(3,4-methylenedioxyphenyl)acetamide 
• 2393-23-9 4-methoxy-benzylamine 
• 250261-64-4 2-(3,4-Methylenedioxyphenyl)acetic pivalic anhydride 
• 108-94-1 cyclohexanone 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 

Relevant academic research and scientific papers

Stereoselective synthesis of (3R*,3aS*,7aS*)-3-aryloctahydroindol2-ones using radical cyclisation: A formal synthesis of (±)-pancracine

The Bu3SnH- or (TMS)3SiH-mediated 5-emlo-trig radical cyclisation of the 7V-(cyclohex-l-enyl)acetamide 10 gives a mixture of the as-fused (3R*,3aS*,7aS*)- and trans-fused (3R*,3aS*,7aK*)-3-aryloctahydroindol-2-ones lia and lib, whereas the 5-cxo-trig radical cyclisation of the N-(cycIohex-2-enyl)acetamide 17 proceeds in a stereoselective manner to give only lia. The latter method has been applied to the synthesis of the 5,11-methanomorphanthridine derivative 30, a key intermediate for the synthesis of (±)-pancracine 1.