250275-15-1

Basic information

• Product Name: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole
• Synonyms: -Boc-hexahydropyrrolo[3,4-c]pyrrole;tert-butyl (3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate;CIS-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE;tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate;(3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate;2-(tert-Butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrole;3-Boc-3,7-diazabicyclo[3.3.0]octane;tert-Butyl cis-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
• CAS NO: 250275-15-1
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.29
• Product Categories: pharmacetical
• Mol File: 250275-15-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 295.397 °C at 760 mmHg
• Flash Point: 132.451 °C
• Appearance: /
• Density: 1.076 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.72±0.20(Predicted)
• CAS DataBase Reference: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole(250275-15-1)
• EPA Substance Registry System: cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole(250275-15-1)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 250275-15-1(Hazardous Substances Data)

Usage

General Description

Cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole is a chemical compound with a unique molecular structure that is used in organic synthesis and medicinal chemistry. It is a bicyclic compound containing a pyrrolopyrrole core and a Boc (tert-butoxycarbonyl) protecting group at the 2-position. cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole is commonly used as a building block in the synthesis of various biologically active molecules and pharmaceuticals. Its unique structure and reactivity make it a versatile and valuable tool in the field of chemical synthesis and drug discovery. Additionally, its stable nature and relatively simple synthesis route make it an attractive option for researchers and chemists working in the field of drug development and organic chemistry.

InChI:InChI=1/C11H20N2O2/c1-11(2,3)15-10(14)13-6-8-4-12-5-9(8)7-13/h8-9,12H,4-7H2,1-3H3

Upstream product

• 370879-53-1 (3aR,6aS)-5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 172739-04-7 cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane 
• 370879-56-4 (3aR,6aS)-tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 

Downstream Products

• 1194688-13-5 (3aR,6aS)-tert-butyl 5-(5-(benzylamino)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194688-41-9 (3aR,6aS)-tert-butyl 5-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1173179-74-2 tert-butyl cis-5-(6-phenylpyridazine-3-yl)-hexahydro-pyrrolo[3,4-c]-pyrrole-2(1H)-carboxylate 
• 1173179-67-3 tert-butyl cis-5-(4-bromophenyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194687-49-4 (3aR,6aS)-tert-butyl 5-(6-(2-methylbenzylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194687-78-9 (3aR,6aS)-tert-butyl 5-(6-(3-isopropoxyphenylcarbamoyl)pyrazin-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194689-10-5 (3aR,6aS)-tert-butyl 5-(5-(benzyl(methyl)carbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194688-54-4 (3aR,6aS)-tert-butyl 5-(5-(2-(trifluoromethyl)benzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194688-58-8 (3aR,6aS)-tert-butyl 5-(5-(2-fluorophenethylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194689-03-6 (3aR,6aS)-tert-butyl 5-(5-(3-iodophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194689-00-3 (3aR,6aS)-tert-butyl 5-(5-(3-isopropoxyphenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194689-22-9 (3aR,6aS)-tert-butyl 5-(5-(4-chlorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194688-82-8 (3aR,6aS)-tert-butyl 5-(5-(m-tolylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 
• 1194688-85-1 (3aR,6aS)-tert-butyl 5-(5-(3,5-dimethylphenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 

Relevant articles and documents

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Novel Octahydropyrrolo[3,4- c ]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate

The preclinical characterization of novel octahydropyrrolo[3,4-c]pyrroles that are potent and selective orexin-2 antagonists is described. Optimization of physicochemical and DMPK properties led to the discovery of compounds with tissue distribution and d

Octahydropyrrolo[3,4-c]pyrrole: A diamine scaffold for construction of either α4β2 or α7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity

A series of 5-(pyridine-3-yl)octahydropyrrolo[3,4-c]pyrroles have been prepared that exhibit high affinity to α4β2 and/or α7 nicotinic acetylcholine receptors (nAChRs). Simple substitution patterns have been identified that allow construction of ligands that are highly selective for either nAChR subtype. The effects of substitution on subtype selectivity provide some insight into the differences in the ligand binding domains of the α4β2 and R7 receptors, especially in regions removed from the cation binding pocket.