370879-56-4

Usage

Uses

Used in Medicinal Chemistry:
cis-5-Benzyl-2-Boc-hexahydropyrrolo[3,4-c]pyrrole is used as a building block for the synthesis of complex organic molecules with potential biological activity. Its unique structure and "cis" configuration allow for the development of new compounds with diverse properties and functions, contributing to the advancement of drug discovery and medicinal chemistry.
Used in Drug Development:
In the pharmaceutical industry, cis-5-Benzyl-2-Boc-hexahydropyrrolo[3,4-c]pyrrole serves as a valuable precursor in the synthesis of novel drug candidates. Its potential biological activity and versatile chemical properties enable the creation of innovative therapeutic agents that can address various medical conditions and diseases.
Used in Organic Synthesis:
cis-5-Benzyl-2-Boc-hexahydropyrrolo[3,4-c]pyrrole is utilized as a key intermediate in organic synthesis, allowing chemists to construct a wide range of complex organic molecules. Its unique structure and "cis" configuration facilitate the development of new synthetic routes and methodologies, expanding the scope of organic chemistry and enabling the synthesis of molecules with novel properties and applications.

InChI:InChI=1/C18H26N2O2/c1-18(2,3)22-17(21)20-12-15-10-19(11-16(15)13-20)9-14-7-5-4-6-8-14/h4-8,15-16H,9-13H2,1-3H3/t15-,16+

Upstream product

• 172739-04-7 cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 370879-53-1 (3aR,6aS)-5-benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 

Downstream Products

• 250275-15-1 tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate 

Relevant academic research and scientific papers

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for

Novel Octahydropyrrolo[3,4- c ]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate

The preclinical characterization of novel octahydropyrrolo[3,4-c]pyrroles that are potent and selective orexin-2 antagonists is described. Optimization of physicochemical and DMPK properties led to the discovery of compounds with tissue distribution and d

Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof

The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R1, X, R2, R3, L1, m, n, p, and q are defined in the specification.

Octahydropyrrolo[3,4-c]pyrrole: A diamine scaffold for construction of either α4β2 or α7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity

A series of 5-(pyridine-3-yl)octahydropyrrolo[3,4-c]pyrroles have been prepared that exhibit high affinity to α4β2 and/or α7 nicotinic acetylcholine receptors (nAChRs). Simple substitution patterns have been identified that allow construction of ligands that are highly selective for either nAChR subtype. The effects of substitution on subtype selectivity provide some insight into the differences in the ligand binding domains of the α4β2 and R7 receptors, especially in regions removed from the cation binding pocket.

Diazabicyclic central nervous system active agents

Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.