250281-90-4

Upstream product

• 831196-83-9 p-benzyloxy-ω-azidoacetophenone 
• 36438-64-9 p-benzyloxystyrene 

Downstream Products

• 250282-06-5 C₆₂H₆₉Br₅N₄O₁₂Si 
• 250282-04-3 C₆₂H₇₀Br₄N₄O₁₂Si 
• 250282-03-2 C₆₂H₇₁Br₃N₄O₁₂Si 
• 250282-07-6 C₅₆H₅₇Br₅N₄O₉Si 
• 250281-97-1 [2-{4-[5-(2-amino-ethyl)-2-methoxy-phenoxy]-3,5-dibromo-phenyl}-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester 
• 250281-95-9 {2-(tert-butyl-dimethyl-silanyloxy)-2-[3,5-dibromo-4-(5-cyanomethyl-2-methoxy-phenoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 250281-96-0 [2-{4-[5-(2-amino-ethyl)-2-methoxy-phenoxy]-3-bromo-phenyl}-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester 
• 250281-94-8 {2-(tert-butyl-dimethyl-silanyloxy)-2-[3,5-dibromo-4-(5-formyl-2-methoxy-phenoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 250281-98-2 {2-[3,5-dibromo-4-(5-formyl-2-methoxy-phenoxy)-phenyl]-2-iodo-ethyl}-carbamic acid tert-butyl ester 
• 250281-93-7 [2-(tert-butyl-dimethyl-silanyloxy)-2-(3,5-dibromo-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 250281-92-6 [2-(3-bromo-4-hydroxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester 
• 250281-91-5 [2-(tert-butyl-dimethyl-silanyloxy)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors

The bacterial deacetylase LpxC is a promising target for the development of antibiotics selectively combating Gram-negative bacteria. To improve the biological activity of the reported benzyloxyacetohydroxamic acid 9 ((S)-N-hydroxy-2-{2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy}acetamide), its hydroxy group was replaced by a triazole ring. Therefore, in divergent syntheses, triazole derivatives exhibiting rigid and flexible lipophilic side chains, different configurations at their stereocenter, and various substitution patterns at the triazole ring were synthesized, tested for antibacterial and LpxC inhibitory activity, and structure-activity relationships were deduced based on docking and binding energy calculations.

Chemoenzymatic synthesis of (R)- and (S)-tembamide, aegeline and denopamine by a one-pot lipase resolution protocol

An efficient synthesis of optically active β-azido alcohols from their ketoazides by a one-pot reduction and an in situ lipase resolution protocol is described. The synthetic utility of this procedure has been illustrated by its application in the practic

A general synthetic route towards bastadins. Part 2: Synthesis of the western part of bastadins 4-16, and fully functionalized macrocycle of bastadin 12

A general synthetic route for the construction of the western part of the macrocyclic bastadins 4-16 is presented. The western and the eastern segments were coupled using the imidazolide of the corresponding acid. The bromine at position Y2 may be added at this advanced step regiospecifically, strengthening the convergence of the presented approach. Finally, the fully functionalized α,ω-aminoacid is cyclized with EDC affording the macrocyclic ring of bastadin-12 in 72% yield (3.5% overall yield).