250282-03-2

Upstream product

• 250281-96-0 [2-{4-[5-(2-amino-ethyl)-2-methoxy-phenoxy]-3-bromo-phenyl}-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 250281-95-9 {2-(tert-butyl-dimethyl-silanyloxy)-2-[3,5-dibromo-4-(5-cyanomethyl-2-methoxy-phenoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 250281-94-8 {2-(tert-butyl-dimethyl-silanyloxy)-2-[3,5-dibromo-4-(5-formyl-2-methoxy-phenoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 250281-93-7 [2-(tert-butyl-dimethyl-silanyloxy)-2-(3,5-dibromo-4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 250281-91-5 [2-(tert-butyl-dimethyl-silanyloxy)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 250281-90-4 (S)-(+)-2-azido-1-(4-benzyloxyphenyl)-1-ethanol 
• 36438-64-9 p-benzyloxystyrene 

Relevant academic research and scientific papers

A general synthetic route towards bastadins. Part 2: Synthesis of the western part of bastadins 4-16, and fully functionalized macrocycle of bastadin 12

A general synthetic route for the construction of the western part of the macrocyclic bastadins 4-16 is presented. The western and the eastern segments were coupled using the imidazolide of the corresponding acid. The bromine at position Y2 may be added at this advanced step regiospecifically, strengthening the convergence of the presented approach. Finally, the fully functionalized α,ω-aminoacid is cyclized with EDC affording the macrocyclic ring of bastadin-12 in 72% yield (3.5% overall yield).