2503-06-2Relevant articles and documents
Preparation method of estra-4,9-diene-3,17-dione
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Paragraph 0033; 0034; 0035, (2019/01/08)
The present invention belongs to the field of synthesis of estra-4,9-diene-3,17-dione and discloses a preparation method of estra-4,9-diene-3,17-dione. The preparation method comprises preparation ofGrignard reagent, Grignard reaction, oxidation and hydrolysis reaction, and tandem cyclization reaction. The synthesis route designed in the present invention is characterized in that delta-lactone isused as the starting material and can be transformed to estra-4,9-diene-3,17-dione through three steps, namely, Grignard reaction, oxidation and hydrolysis reaction, and tandem cyclization reaction.The preparation method of estra-4,9-diene-3,17-dione is low in cost, low in environmental pollution, low in water consumption, easy to control, and high in yield with no need for highly toxic chemicals.