54201-84-2

Basic information

• Product Name: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol
• Synonyms: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol;17-Hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal);3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene;3,3,20,20-bis(ehtylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11)-diene;19-Norpregna-5(10),9(11)-diene-3,20-dione,17-hydroxy-, cyclic 3,20-bis(1,2-ethanediyl acetal), (5a,10a)-;3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19/;17-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal);3,20-BIS(ETHYLENEDIOXY)-19-NORPREGNA-5(10),9(11)-DIENE-17-OL
• CAS NO: 54201-84-2
• Molecular Formula: C₂₄H₃₄O₅
• Molecular Weight: 402.52376
• EINECS: 1308068-626-2
• Product Categories: API
• Mol File: 54201-84-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 568 °C at 760 mmHg
• Flash Point: 297.3 °C
• Appearance: /
• Density: 1.25
• PKA: 14.95±0.40(Predicted)
• CAS DataBase Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)
• EPA Substance Registry System: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)

Safety Data

• Hazardous Substances Data: 54201-84-2(Hazardous Substances Data)

Usage

General Description

3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol is a synthetic compound with a complex chemical structure. It belongs to the class of steroids and is specifically a norpregnane derivative. The compound contains two ethylenedioxy groups and a hydroxyl group, and its molecular formula is C25H32O4. It is often used in the field of medicinal chemistry and pharmaceutical research for its potential biological activities, especially in relation to hormone receptors and related pathways. The compound may have potential applications in the development of new drugs for hormone-related conditions and diseases.

Upstream product

• 2503-06-2 estra-4,9-diene-3,17-dione 
• 107-21-1 ethylene glycol 
• 14340-01-3 17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione 
• 5571-36-8 ethylene deltenone 

Downstream Products

• 54201-83-1 C₂₄H₃₄O₆ 
• 25092-42-6 (11β,17α)-17-hydroxy-11-methyl-norpregna-4-en-3,20-dione 
• 14340-01-3 17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione 
• 244206-54-0 C₃₄H₅₁NO₆Si 
• 244206-51-7 3,20-bis-ethylenedioxy-5α,17α-dihydroxy-11β-(4-aminophenyl)-19-norpregn-9-ene 
• 244206-53-9 11β-(4-N-trifluoroacetamidophenyl)-17α-acetoxy-19-norpregna-4,9-diene-3,20-dione 
• 244206-56-2 17α-acetoxy-11β-(4-N-acetyl-N-methylaminophenyl)-19-norpregna-4,9-diene-3,20-dione 
• 244206-52-8 11β-(4-aminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 159681-67-1 11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 126690-41-3 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene 
• 159811-51-5 CDB-3236 
• 54201-83-1 5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal) 

Relevant articles and documents

Synthesis method of ulipristal acetate intermediate

The invention provides a synthesis method of a ulipristal acetate intermediate. The synthesis method of the ulipristal acetate intermediate comprises the following steps: 1) a cyano reaction: dissolving a 3-ketal compound (I) in ethyl acetate, adding acetone cyanohydrin and triethylamine, and carrying out reacting to obtain a 17-cyanohydrin compound (II); 2) a protective reaction: adding dichloromethane, imidazole and a silanization reagent into a wet product of the 17-cyanohydrin compound (II), keeping the above raw materials at a temperature of 20-25 DEG C until the raw materials react completely so as to obtain a protected compound (III); 3) a methylation reaction: adding an ether solvent into a wet product of the protected compound (III), controlling a temperature to be -10 DEG C to 5DEG C, dropwise adding a lithium methide solution, carrying out a reaction with a temperature controlled to be -40 DEG C to 5 DEG C until the raw materials are completely reacted so as to obtain a methide (IV-1) solution; and 4) a ketalation reaction: adding ethylene glycol, triethyl orthoformate and p-toluenesulfonic acid (PTS) into the methide (IV-1) solution, and carrying out a heat-preserved reaction at a temperature of 20-25 DEG C until the raw materials are completely reacted so as to obtain a diketal (V).

Preparation method of ulipristal acetate diketal

The invention discloses a preparation method of ulipristal acetate diketal. Dihydroxyprogesterone dehydrogenate 1 is used as the raw material to prepare an important intermediate of sterides, namely ulipristal acetate diketal 8; a reaction formula is shown in the attached figure. The preparation method has the advantages that the dihydroxyprogesterone dehydrogenate 1 is used as a starting raw material, seven steps are performed, and the ulipristal acetate diketal with weight total yield rate of 65% or above can be obtained; the reaction is simple, the selectivity is good, and the preparation method is suitable for industrialization production.

Method for preparing di-ketal

The invention discloses a method for preparing di-ketal. An open-loop substance 1 used as a raw material is subjected to cyanide reaction, ketalation, etherifying reaction, oxidization, decarboxylic reaction, diene reaction and di-ketal reaction to obtain di-ketal 9, and reaction formulas are as follows: as shown in the description.