25032-16-0 Usage
Description
1-(4-phenylpiperazin-1-yl)propan-2-amine is a chemical compound that belongs to the class of piperazine derivatives. It is a psychoactive drug with stimulant and entactogen effects, known to act as a selective serotonin releasing agent. 1-(4-phenylpiperazin-1-yl)propan-2-amine has been studied for its potential therapeutic applications in various conditions, including depression, anxiety disorders, and due to its neuroprotective and neuroregenerative properties.
Uses
Used in Pharmaceutical Industry:
1-(4-phenylpiperazin-1-yl)propan-2-amine is used as a therapeutic agent for the treatment of [application reason] depression and anxiety disorders. Its mechanism of action involves acting as a selective serotonin releasing agent, which can help alleviate the symptoms of these conditions.
Used in Research and Development:
In the field of neuroscience, 1-(4-phenylpiperazin-1-yl)propan-2-amine is used as a research compound to study the effects of selective serotonin release on the brain. This can contribute to the understanding of the underlying mechanisms of mood disorders and the development of new treatments.
Used in Neuroprotection and Neuroregeneration:
Due to its potential neuroprotective and neuroregenerative properties, 1-(4-phenylpiperazin-1-yl)propan-2-amine is used in the development of treatments for neurological conditions where these properties are beneficial, such as neurodegenerative diseases or conditions resulting from brain injury.
Check Digit Verification of cas no
The CAS Registry Mumber 25032-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,0,3 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25032-16:
(7*2)+(6*5)+(5*0)+(4*3)+(3*2)+(2*1)+(1*6)=70
70 % 10 = 0
So 25032-16-0 is a valid CAS Registry Number.
25032-16-0Relevant articles and documents
Synthesis, biological evaluation, and molecular modeling studies of chiral chloroquine analogues as antimalarial agents
Kondaparla, Srinivasarao,Debnath, Utsab,Dola, Vasantha Rao,Sinha, Manish,Katti, Seturam B.,Soni, Awakash,Srivastava, Kumkum,Puri, Sunil K.
, (2019/01/05)
In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents. In vitro as well as in vivo studies revealed that compound 7c showed potent activity (in vitro 50% inhibitory concentration, 56.98 nM for strain 3D7 and 97.76 nM for strain K1; selectivity index in vivo [up to at a dose of 12.5 mg/kg of body weight], 3,510) as a new lead antimalarial agent. Other compounds (compounds 6b, 6d, 7d, 7h, 8c, 8d, 9a, and 9c) also showed moderate activity against a CQ-sensitive strain (3D7) and superior activity against a CQ-resistant strain (K1) of Plasmodium falciparum. Furthermore, we carried out docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of all in-house data sets (168 molecules) of chiral CQ analogues to explain the structure-activity relationships (SAR). Our new findings specify the significance of the H-bond interaction with the side chain of heme for biological activity. In addition, the 3D-QSAR study against the 3D7 strain indicated the favorable and unfavorable sites of CQ analogues for incorporating steric, hydrophobic, and electropositive groups to improve the antimalarial activity.
