250343-69-2Relevant articles and documents
The powerful effect of N-aryl substitution in promoting the thermal rearrangement of 5-spirocyclopropaneisoxazolidines
Cordero, Franca M.,Barile, Ingrid,De Sarlo, Francesco,Brandi, Alberto
, p. 6657 - 6660 (1999)
N-Alkyl 5-spirocyclopropaneisoxazolidines rearrange to tetrahydropyridone derivatives by heating. The presence of a phenyl ring on the nitrogen atom significantly reduces the rearrangement temperature. This effect is enhanced by electron-donating substituents and reduced by electron- withdrawing substituents on the phenyl ring.
