250595-72-3

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 250595-71-2 {(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-acetic acid methyl ester 
• 312709-29-8 (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 250595-68-7 [(1S,2R)-1-Allyl-2-((R)-2-hydroxy-1-methyl-ethyl)-cyclopentyl]-carbamic acid tert-butyl ester 
• 250595-66-5 6a-allyl-3-methyl-2-oxo-hexahydro-cyclopenta[b]pyrrole-1-carboxylic acid tert-butyl ester 
• 250595-65-4 6a-allyl-2-oxo-hexahydro-cyclopenta[b]pyrrole-1-carboxylic acid tert-butyl ester 
• 250595-64-3 (3aR,6aS)-6a-Allyl-hexahydro-cyclopenta[b]pyrrol-2-one 
• 161779-70-0 (3R,5aR,8aS)-3-phenyl-hexahydro-1-oxa-3a-aza-cyclopenta[c]pentalen-4-one 
• 104115-44-8 (2-oxocyclopent)acetic acid 
• 250595-70-1 (Z)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 1026515-31-0 (Z)-6-{(1R,2R)-1-Amino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 250595-69-8 {1-allyl-2-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-carbamic acid tert-butyl ester 
• 250595-67-6 (R)-2-((1R,2S)-2-Allyl-2-tert-butoxycarbonylamino-cyclopentyl)-propionic acid 
• 250595-63-2 (3aR,6aS)-6a-Allyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-hexahydro-cyclopenta[b]pyrrol-2-one 

Downstream Products

• 250595-74-5 C₃₇H₅₃NO₃Si 
• 250595-73-4 C₃₇H₅₃NO₄Si 

Relevant academic research and scientific papers

Total synthesis of (+)-halichlorine: An inhibitor of VCAM-1 expression

The diastereoselective addition of the highly functionalized organozinc compound 1 to the aldehyde 2 in the presence of the chiral amino alcohol 3 (a??4) is a key step in the first total synthesis of (+)-halichlorine. A series of protections/deprotections

Studies towards the total synthesis of halichlorine: Asymmetric synthesis of the spiroquinolizidine subunit

The C1-C15 spiroquinolizidine subunit (cf. 2) of the marine natural product halichlorine (1) was prepared in 12 steps starting from the known 'Meyers-lactam' 5. The synthesis involves a B-alkyl-Suzuki coupling followed by a highly stereoselective intramolecular Michael addition and an intramolecular Mannich ring closure.