250595-63-2

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 104115-44-8 (2-oxocyclopent)acetic acid 
• 161779-70-0 (3R,5aR,8aS)-3-phenyl-hexahydro-1-oxa-3a-aza-cyclopenta[c]pentalen-4-one 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 1026515-31-0 (Z)-6-{(1R,2R)-1-Amino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 250595-71-2 {(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-acetic acid methyl ester 
• 250595-74-5 C₃₇H₅₃NO₃Si 
• 250595-70-1 (Z)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 250595-72-3 4-{(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-3-oxo-butyric acid tert-butyl ester 
• 250595-73-4 C₃₇H₅₃NO₄Si 
• 312709-29-8 (E)-6-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-hex-2-enoic acid methyl ester 
• 403507-08-4 (E)-4-[(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-(2,2,2-trifluoro-acetyl)-6-aza-spiro[4.5]dec-7-yl]-2-methyl-but-2-enoic acid ethyl ester 
• 403507-13-1 (2E,4E)-8-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-2-methyl-octa-2,4-dienoic acid ethyl ester 
• 403507-05-1 (2E,4E)-8-{(1R,2R)-1-tert-Butoxycarbonylamino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-2-methyl-octa-2,4-dienoic acid ethyl ester 
• 403507-15-3 (E)-4-{(1R,5S,7R)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-2-methyl-but-2-enoic acid ethyl ester 
• 403507-07-3 (E)-4-{(1R,5S,7R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-aza-spiro[4.5]dec-7-yl}-2-methyl-but-2-enoic acid ethyl ester 
• 403507-14-2 (2E,4E)-8-{(1R,2R)-1-Amino-2-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-2-methyl-octa-2,4-dienoic acid ethyl ester 
• 403507-06-2 (2E,4E)-8-{(1R,2R)-1-Amino-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentyl}-2-methyl-octa-2,4-dienoic acid ethyl ester 

Relevant academic research and scientific papers

Concise stereoselective routes to advanced intermediates related to natural and unnatural pinnaic acid

Important intermediates: In an effort to synthesize and determine the stereo-chemistry of pinnaic acid, C14-epimeric aldehydes 1 and 2 were generated from Meyers' lactam 3. A key step in the parallel syntheses is a highly stereoselective vinylogous Michae

Total synthesis of (+)-halichlorine: An inhibitor of VCAM-1 expression

The diastereoselective addition of the highly functionalized organozinc compound 1 to the aldehyde 2 in the presence of the chiral amino alcohol 3 (a??4) is a key step in the first total synthesis of (+)-halichlorine. A series of protections/deprotections

Studies towards the total synthesis of halichlorine: Asymmetric synthesis of the spiroquinolizidine subunit

The C1-C15 spiroquinolizidine subunit (cf. 2) of the marine natural product halichlorine (1) was prepared in 12 steps starting from the known 'Meyers-lactam' 5. The synthesis involves a B-alkyl-Suzuki coupling followed by a highly stereoselective intramolecular Michael addition and an intramolecular Mannich ring closure.