250649-08-2

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 598-50-5 N-Methylurea 

Downstream Products

• 250649-42-4 Benzyl 4-(2,3-dichlorophenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 250649-80-0 4-(2,3-Dichlorophenyl)-2-oxo-1,3,6-trimethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and reactions of Biginelli-compounds. Part 23: Chemoenzymatic syntheses of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Enantiomerically pure dihydropyrimidones (DHPMs) were prepared by lipase-catalyzed enzymatic resolution of two types of activated DHPM esters. In the first model series, pivaloyloxymethyl-activated DHPM C5-esters 10a-c were resolved on an analytical scale

Polyphosphate ester-mediated synthesis of dihydropyrimidines. Improved conditions for the Biginelli reaction

Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction c