250665-25-9

Upstream product

• 121-43-7 Trimethyl borate 
• 151-10-0 1,3-Dimethoxybenzene 
• 16932-45-9 1-bromo-2,6-dimethoxybenzene 

Downstream Products

• 309977-94-4 C₈H₁₀BFO₄ 
• 500711-49-9 9-(2,6-dimethoxyphenyl)-2-{2,6-dimethoxy-4[(2-tetrahydropyranyloxy)methyl]phenyl}-1,10-phenanthroline 
• 500711-50-2 2-(4-chloromethyl-2,6-dimethoxyphenyl)-9-(2,6-dimethoxyphenyl)-1,10-phenanthroline 
• 500711-47-7 2-chloro-9-(2,6-dimethoxyphenyl)-1,10-phenanthroline 
• 124318-69-0 2,9-bis(2,6-dimethoxyphenyl)-3-ethynyl-[1,10]-phenanthroline 
• 124318-70-3 2-(2',6'-Dimethoxyphenyl)-1,10-phenanthroline 
• 848409-29-0 [(S)-6-(2,6-Dimethoxy-phenyl)-chroman-3-yl]-dimethyl-amine 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 

Relevant academic research and scientific papers

Towards allosteric receptors synthesis of β-cyclodextrin- functionalised 2,2'-bipyridines and their metal complexes

Herein, we present three new 2,2'-bipyridines that carry two β-cyclodextrin moieties in different substitution patterns. When coordinated by zinc(II) or copper(I) ions (or their complexes), these compounds undergo conformational changes and switch between

Synthesis of substituted azulenes via Pt(II)-Catalyzed ring-expanding cycloisomerization

Substituted azulenes, valuable structures for electronic devices and pharmaceuticals, have been synthesized by the platinum(II)-catalyzed intramolecular ring-expanding cycloisomerization of 1-en-3-yne with ortho-disubstituted benzene. This novel method provides an alternative route for the efficient synthesis of substituted azulenes. The reaction mechanism of selected catalytic transformations was explored using density functional calculations.

Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor

The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT 7 receptor affinities that varies from nM to μM, indicating that this small set of derivatives constitute a nove

Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group

The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.

A facile route to Aryl-substituted 1,10-phenanthrolines by means of Suzuki coupling reactions between substituted areneboronic acids and halogeno-1,10-phenanthrolines

Twelve new mono- or diaryl-substituted 1,10-phenanthrolines (17 and 18) have been synthesized. The key step is a Suzuki coupling reaction between the substituted areneboronic acids 6, 11, and 15 and the mono- and dihalo-1,10-phenanthrolines 16. The syntheses of bis-ortho-substituted boronic acids 6, 11, and 15 from substituted arenes 5 or substituted bromoarenes 10 and 14 by lithiation and subsequent treatment with trimethyl borate is described. Not only 2,9-diiodo- (16c) but also 2,9-dichloro-1,10-phenanthroline (16b) can be used with good yields (65-92%) in the described Suzuki coupling. For the syntheses of unsymmetrically substituted 1,10-phenanthrolines 18b, 18i, and 18j, the use of 2- chloro-9-iodo-1,10-phenanthroline is not necessary; two different bis-ortho-substituted arene rings can be introduced stepwise in 46 to 64% total yield. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.