250665-25-9Relevant articles and documents
Synthesis of substituted azulenes via Pt(II)-Catalyzed ring-expanding cycloisomerization
Usui, Kazuteru,Tanoue, Kensuke,Yamamoto, Kosuke,Shimizu, Takashi,Suemune, Hiroshi
supporting information, p. 4662 - 4665 (2015/01/16)
Substituted azulenes, valuable structures for electronic devices and pharmaceuticals, have been synthesized by the platinum(II)-catalyzed intramolecular ring-expanding cycloisomerization of 1-en-3-yne with ortho-disubstituted benzene. This novel method provides an alternative route for the efficient synthesis of substituted azulenes. The reaction mechanism of selected catalytic transformations was explored using density functional calculations.
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor
Holmberg, Paer,Tedenborg, Lars,Rosqvist, Susanne,Johansson, Anette M.
, p. 747 - 750 (2007/10/03)
The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT 7 receptor affinities that varies from nM to μM, indicating that this small set of derivatives constitute a nove
A facile route to Aryl-substituted 1,10-phenanthrolines by means of Suzuki coupling reactions between substituted areneboronic acids and halogeno-1,10-phenanthrolines
Luening, Ulrich,Abbass, Michael,Fahrenkrug, Frank
, p. 3294 - 3303 (2007/10/03)
Twelve new mono- or diaryl-substituted 1,10-phenanthrolines (17 and 18) have been synthesized. The key step is a Suzuki coupling reaction between the substituted areneboronic acids 6, 11, and 15 and the mono- and dihalo-1,10-phenanthrolines 16. The syntheses of bis-ortho-substituted boronic acids 6, 11, and 15 from substituted arenes 5 or substituted bromoarenes 10 and 14 by lithiation and subsequent treatment with trimethyl borate is described. Not only 2,9-diiodo- (16c) but also 2,9-dichloro-1,10-phenanthroline (16b) can be used with good yields (65-92%) in the described Suzuki coupling. For the syntheses of unsymmetrically substituted 1,10-phenanthrolines 18b, 18i, and 18j, the use of 2- chloro-9-iodo-1,10-phenanthroline is not necessary; two different bis-ortho-substituted arene rings can be introduced stepwise in 46 to 64% total yield. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).