250672-65-2

Basic information

• Product Name: (R)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-1H-INDOL-4-OL
• Synonyms: Lucigenol;(R)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-1H-INDOL-4-OL;1H-Indol-4-ol, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-
• CAS NO: 250672-65-2
• Molecular Formula: C14H18N2O
• Molecular Weight: 230.31
• Product Categories: Heterocycles series
• Mol File: 250672-65-2.mol

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 422.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• PKA: 9.87±0.40(Predicted)
• CAS DataBase Reference: (R)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-1H-INDOL-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-1H-INDOL-4-OL(250672-65-2)
• EPA Substance Registry System: (R)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-1H-INDOL-4-OL(250672-65-2)

Safety Data

• Hazardous Substances Data: 250672-65-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(R)-(+)-3-(N-methylpyrrolidin-2-ylmethyl)-4-hydroxyindole is utilized as a building block for the synthesis of new bioactive compounds. Its unique structure and chirality make it a valuable component in the creation of pharmaceutical agents with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-(+)-3-(N-methylpyrrolidin-2-ylmethyl)-4-hydroxyindole is employed for its potential therapeutic properties. While further research is necessary to fully understand its biological activity, it may contribute to the development of new medications with specific medicinal uses.

Upstream product

• 250672-59-4 3-bromo-1-(tert-butyldimethylsilyl)-4-benzyloxyindole 
• 20289-26-3 4-benzyloxy-1H-indole 
• 250672-62-9 (R)-(+)-3-(N-methylpyrrolidin-2-ylcarbonyl)-4-benzyloxyindole 
• 250672-60-7 (S)-(-)-3-(N-methylpyrrolidin-2-ylcarbonyl)-4-benzyloxyindole 

Relevant articles and documents

3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS

The present application relates to 3-cyclic amine-indole derivatives of general Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses, and other neurological diseases, disorders and conditions. Formula (I)

Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain

The enantiomers of 3-(N-methylpyrrolidin-2-ylmethyl)-5-methoxyindole, 1, and 3-(N-methylpyrrolidin-2-ylmethyl)-4-hydoxyindole, 3, were prepared using an asymmetric synthesis that employed (+)- or (-)-proline. A new approach was developed that had certain