25069-93-6Relevant articles and documents
Nitrogen-Nitrogen Bond Formation via a Substrate-Bound Anion at a Mononuclear Nickel Platform
Kosobokov, Mikhail D.,Sandleben, Aaron,Vogt, Nicolas,Klein, Axel,Vicic, David A.
, p. 521 - 525 (2018)
The nickel-C4F8 fragment coordinates an aminoaryl N-H ketimine to form a stable complex, which upon treatment with base and oxidant leads to an N-N bond-forming reaction and the release of indazole product. A key and previously unidentified intermediate in the formation of the indazole was a diimine complex of nickel bearing significant charge on the aryl ring that initially contained the amine substituent. The C4F8 coligand was key for the redox transformation and for stabilization of the intermediate for characterization.
Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines
Chen, Cheng-Yi,He, Fengxian,Tang, Guangrong,Yuan, Huiqing,Li, Ning,Wang, Jinmin,Faessler, Roger
, p. 2395 - 2401 (2018/02/23)
An efficient synthesis of quinazolines based on an iron-catalyzed C(sp3)-H oxidation and intramolecular C-N bond formation using tert-BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N-H ketimine species. The FeCl2-catalyzed C(sp3)-H oxidation of the alkyl group employing tert-BuOOH followed by intramolecular C-N bond formation and aromatization afforded a wide variety of 2,4-disubstituted quinazolines in good to excellent yields.
A Synthesis of 1H-Indazoles via a Cu(OAc)2-Catalyzed N-N Bond Formation
Chen, Cheng-Yi,Tang, Guangrong,He, Fengxian,Wang, Zhaobin,Jing, Hailin,Faessler, Roger
, p. 1690 - 1693 (2016/04/26)
A facile synthesis of 1H-indazoles featuring a Cu(OAc)2-catalyzed N-N bond formation using oxygen as the terminal oxidant is described. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to o-aminoar
