25070-24-0Relevant academic research and scientific papers
Valine amide carbamate derivative containing propargyloxy group and application thereof
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, (2017/08/25)
The invention relates to a valine amide carbamate derivative containing a propargyloxy group and a pharmaceutically acceptable salt thereof, belonging to the field of botanical bactericides. The valine amide carbamate derivative has a general formula (I) as shown in the specification, and the substituent R in the general formula (I) is as defined in the specification. The invention also relates to a preparation method for the compound as shown in the general formula (I), an intermediate specially prepared for development of the compound and application of the compound to prevention and treatment of plant diseases.
Reaction of n,n-dioxyenamines with anhydrides of carboxylic and sulfonic acids; A new method for the synthesis of a-hydroxyoxime derivatives
Tabolin, Andrey A.,Lesiv, Alexey V.,Ioffe, Sema L.
experimental part, p. 3099 - 3105 (2010/01/15)
The reactions of N,N-dioxyenamines with carboxylic and sulfonic acid anhydrides were investigated. A new method for the synthesis of a-hydroxyoxime derivatives via the reaction of N,N-dioxyenamines with trifluoroacetic anhydride is described.
Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation
Park, Chan Pil,Nagle, Advait,Cheol, Hwan Yoon,Chen, Chiliu,Kyung, Woon Jung
supporting information; scheme or table, p. 6231 - 6236 (2009/12/08)
(Chemical Equation Presented) Formal aromatic C-H insertion of rhodium(II) carbenoid was intensively investigated to develop a new methodology and probe its mechanism. Contrasting with the previously proposed direct C-H insertion, the mechanism was revealed to be electrophilic aromatic substitution, which was supported by substituent effects on the aromatic ring and a secondary deuterium kinetic isotope effect. Various isoquinolinones were synthesized intramolecularly via six-membered ring formation with high regioand diastereoselectivity, while averting the common Buchner-type reaction. Intermolecularly, dirhodium catalyzed formal aromatic C-H insertion on electron-rich aromatics was also achieved.
Improved Chiral Derivatizing Agents for the Chromatographic Resolution of Racemic Primary Amines
Pirkle, William H.,Simmons, Kirk A.
, p. 2520 - 2527 (2007/10/02)
Several 4- and/or 5-aryl-substituted 2-oxazolidones have been prepared and studied as chiral derivatizing agents (CDA) for the chromatographic resolution of chiral primary amines via diastereomeric allophanates.The diastereomeric allophanates derived from either racemic primary amines and cis-4,5-diphenyl-2-oxazolidone-3-carbamyl chloride or racemic isocyanates and cis-4,5-diphenyl-2-oxazolidone show sufficient NMR chemical shift differences and chromatographic separability that this heterocyclic system should prove to be a very useful CDA for the chromatographic resolution and determination of the absolute configuration of a variety of chiral primary amines.The diastereomeric allophanates are readily hydrolyzed to return both chiral components of the allophanates in excellent yield.Both solution and adsorbed conformations of these allophanates are discussed in reference to the determination of the absolute configuration of the allophanates (and hence of the chiral primary amine) from the senses of NMR nonequivalence between and chromatographic elution order of the diastereomers.
