250723-62-7

Basic information

• Product Name: 3-(4-cyano-3-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(4-propyl-benzenesulfonylamino)-propionamide
• CAS NO: 250723-62-7
• Molecular Weight: 471.596
• Mol File: 250723-62-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-cyano-3-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(4-propyl-benzenesulfonylamino)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-cyano-3-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(4-propyl-benzenesulfonylamino)-propionamide(250723-62-7)
• EPA Substance Registry System: 3-(4-cyano-3-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(4-propyl-benzenesulfonylamino)-propionamide(250723-62-7)

Safety Data

• Hazardous Substances Data: 250723-62-7(Hazardous Substances Data)

Upstream product

• 146949-07-7 4-n-propylbenzenesulfonyl chloride 
• 250723-58-1 [2-(4-cyano-3-fluoro-phenyl)-1-(cyclopentyl-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 250723-55-8 2-acetylamino-3-(4-cyano-3-fluoro-phenyl)-propionic acid 
• 85070-67-3 2-fluoro-4-methylbenzonitrile 
• 452-74-4 4-bromo-3-fluorotoluene 
• 222978-03-2 4-cyano-3-fluorobenzylbromide 

Relevant articles and documents

Fluorobenzamidrazone thrombin inhibitors: Influence of fluorine on enhancing oral absorption

LB30057 (1) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound 1 and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound 2 demonstrated a 3-fold increase in absorption.