2508-01-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-chloroethyl)oxazolidin-2-one is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in cancer treatment. Its unique structure allows for the development of novel drugs that can target specific biological pathways involved in cancer progression.
Used in Chemical Industry:
In the chemical industry, 3-(2-chloroethyl)oxazolidin-2-one is utilized as a building block for the creation of various chemical products. Its reactivity and functional groups make it a valuable component in the synthesis of complex molecules with specific properties and applications.
Used in Engineering Catalysts:
3-(2-chloroethyl)oxazolidin-2-one is used as an engineering catalyst for selective ester hydrogenation. Its unique chemical properties enable it to facilitate the hydrogenation process, leading to the production of specific ester compounds with high selectivity and efficiency. This application is particularly relevant in the development of green and sustainable chemical processes.

InChI:InChI=1/C5H8ClNO2/c6-1-2-7-3-4-9-5(7)8/h1-4H2

Upstream product

• 3356-88-5 N-(2'-hydroxyethyl)-2-oxazolidone 
• 101973-67-5 (2-chloro-ethyl)-carbamic acid-(2-chloro-ethyl ester) 
• 20729-41-3 acetaldehyde imine 
• 627-11-2 2-Chloroethyl chloroformate 
• 107-04-0 1-Bromo-2-chloroethane 
• 124-38-9 carbon dioxide 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 7506-80-1 2-hydroxyethyl (2-hydroxyethyl)carbamate 

Downstream Products

• 4271-26-5 N-vinyl-2-oxazolidone 
• 52548-37-5 3-[2-(4-benzyl-piperazin-1-yl)-ethyl]-oxazolidin-2-one 
• 114458-68-3 3-(2-phenylsulfanyl-ethyl)-oxazolidin-2-one 
• 22455-79-4 3-(2-anilino-ethyl)-oxazolidin-2-one 
• 22455-78-3 3-[2-(N'-phenyl-hydrazino)-ethyl]-oxazolidin-2-one 
• 13621-80-2 3-(2-phenoxy-ethyl)-oxazolidin-2-one 
• 1421060-11-8 carbonyl chlorohydride{bis[2-(dicyclohexylphosphino)ethyl]amine}ruthenium(II) 
• 86184-78-3 N-(7-chloro-4-quinolyl)-anthranilic acid β-(2-oxo-3-oxazolidinyl)-ethyl ester 
• 86184-79-4 N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid β-(2-oxo-3-oxazolidinyl)-ethyl ester 
• 59849-49-9 (-)-(R)-3-<2-<4-(8-Fluor-10,11-dihydro-2-methyldibenzo thiepin-10-yl)-1-piperazinyl>-aethyl>-2-oxazolidinon 
• 104087-43-6 3-(2-{4-[(1S,3R)-3-(4-Fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-oxazolidin-2-one 
• 104087-44-7 3-(2-{4-[(1R,3S)-6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-oxazolidin-2-one 
• 131727-89-4 N-(phenyl)-N-[1-(2-(2,3,4,5-tetrahydro-2-oxo-oxazol-3-yl)ethyl)-4methoxycarbonyl-4-piperidinyl]-propanamide 

Relevant academic research and scientific papers

Synthesis of N-vinyl-2-oxazolidone: A commercially important intermediate

An improved synthesis of N-vinyl-2-oxazolidone starting from ethanolamine has been developed.

Chemoselective Hydrogenation of Alkynes to (Z) -Alkenes Using an Air-Stable Base Metal Catalyst

A highly selective hydrogenation of alkynes using an air-stable and readily available manganese catalyst has been achieved. The reaction proceeds under mild reaction conditions and tolerates various functional groups, resulting in (Z)-alkenes and allylic alcohols in high yields. Mechanistic experiments suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperativity.

N,N-BIS(2-DIALKYLPHOSPHINOETHYL)AMINE-BORANE COMPLEX AND PRODUCTION METHOD THEREFOR, AND METHOD FOR PRODUCING RUTHENIUM COMPLEX CONTAINING N,N-BIS(2-DIALKYLPHOSPHINOETHYL)AMINE AS LIGAND

The purpose of the present invention is to provide an N,N-bis(2-dialkylphosphinoethyl)amine-borane complex which is a ruthenium complex that exhibits excellent catalytic activity in a hydrogenation reaction, etc., and a production method therefor, and a method for efficiently producing a ruthenium complex containing N,N-bis(2-dialkylphosphinoethyl)amine as a ligand. The present invention is capable of efficiently producing an amine-borane complex (3) by reacting an oxazolidinone compound (1) with a dialkylphosphine-borane compound (2) in the presence of a base. The present invention is also capable of efficiently producing a ruthenium complex (5) by reacting the amine-borane complex (3) with a ruthenium compound (4) in the presence of an amine. (In the formula, a solid line, a dashed line, B, C, H, L1-L3, LG, n, N, O, P, Ru, X, and R1-R10 are as defined in the description.)

N-(PHOSPHINOALKYL)-N-(THIOALKYL)AMINE DERIVATIVE, METHOD FOR PRODUCING SAME, AND METAL COMPLEX THEREOF

The purpose of the present invention is to provide: a ligand that is useful in a catalytic organic synthetic reaction; a method for producing said ligand; and a metal complex that is useful as a catalyst in an organic synthetic reaction. The present invention provides a compound represented by general formula (1A), a method for producing said compound, and a metal complex including said compound as a ligand. (In the formula, H, N, P, S, L, R1, R2, R3, Q1, and Q2 have the meaning as defined in the Description.)

THIENOPYRIMIDINES, PROCESS FOR PREPARING THE SAME AND USE THEREOF

The present invention provides a thienopyrimidine compound, represented by the formula???[wherein, R1 is C1-4 alkyl, R2 is (1) phenyl optionally having a substituent such as amino, mono C1-4 alkylamino and di C1-4 alkylamino, or (2) a heterocyclic group optionally having a substituent such as amino, mono C1-4 alkylamino and di C1-4 alkylamino and the like, R3 is a hydrogen atom or C1-4 alkyl, R4 is C1-4 alkyl optionally having a substituent such as C1-4 alkoxy-carbonyl, carboxyl, mono C1-4 alkylamino and N-C1-4 alkyl-N-C7-10 aralkylamino and the like] or a salt thereof, which has antagonistic action for gonadotropin-releasing hormone.