25080-83-5

Basic information

• Product Name: m-Nitrotrifluoroacetanilide
• Synonyms: N-(m-Nitrophenyl)-2,2,2-trifluoroacetamide;AcetaMide, 2,2,2-trifluoro-N-(3-nitrophenyl)-;m-Nitrotrifluoroacetanilide
• CAS NO: 25080-83-5
• Molecular Formula: C₈H₅F₃N₂O₃
• Molecular Weight: 234
• Mol File: 25080-83-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: m-Nitrotrifluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: m-Nitrotrifluoroacetanilide(25080-83-5)
• EPA Substance Registry System: m-Nitrotrifluoroacetanilide(25080-83-5)

Safety Data

• Hazardous Substances Data: 25080-83-5(Hazardous Substances Data)

Upstream product

• 99-09-2 3-nitro-aniline 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 7553-56-2 iodine 
• 331843-24-4 (S)-3-Acetylamino-N-((S)-1-{3-[methoxycarbonylmethyl-(2,2,2-trifluoro-acetyl)-amino]-phenylcarbamoyl}-2-methyl-propyl)-succinamic acid benzyl ester 
• 331843-25-5 m(Ac-L-Asp-L-Val-NH)-N-phenylglycine 
• 331843-22-2 m-(Val-NH)-N-trifluoroacetyl-N-phenylglycine methyl ester 
• 331843-19-7 m-nitro-N-trifluoroacetyl-N-phenylglycine methyl ester 
• 619-26-1 N-methyl-3-nitroaniline 

Relevant articles and documents

Effect of Cyclodextrins on the Hydrolysis of Amides

The hydrolysis of p-nitrotrifluoroacetanilide (1), trifluoroacetanilide (2), m-nitrotrifluoroacetanilide (3), and p-nitroacetanilide (4) was studied in the presence of cyclodextrins.The reactions of 1 are catalyzed by α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) and also by hydroxypropyl)cyclodextrin (HPCD).The hydrolysis of 4 is catalyzed by β-CD.The reaction of 2 is inhibited by β-CD and so is the reaction of 3 by HPCD.Copounds 1 and 4 form two types of inclusion coplexes with β-CD, a 1:1 and a 1:2 substrate:cyclodextrin complex.Both types of complexesreact faster than the free substrate, and for 1 at pH = 7 all the catalysis is due to the reaction of the 1:2 complex since the 1:1 complex reacts at about the same rate as the free substrate.The results are explained in terms of two mechanisms: one which involves the acylation of CD by the amides and another which predominates at neutral pH where the two cyclodextrins coplexing the substrate stabilize the transition state for water addition.

Inhibitors of IMPDH enzyme

The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.